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目的探讨人尿表皮生长因子（hEGF）与某些胃部疾病的关系。方法随机检查244例胃部疾病患者和66例正常人，用放射免疫分析法测定随意尿hEGF的水平。结果①胃癌组患者尿bEGF水平明显升高，与消化性溃疡组、慢性胃炎组及对照组比较有明显差异（P＜0.01）；②消化性溃疡组和慢性胃炎组尿hEGF水平明显升高者中76．5％的胃粘膜伴有间变或肠化，且随着hECF水平升高胃粘膜间变或肠化所占的比例有所增加。结论尿hEGF水平升高与胃癌及胃部癌前病变可能有一定联系。
Objective To investigate the relationship between human urothelial epidermal growth factor (hEGF) and some gastric diseases. Methods Totally 244 patients with gastric diseases and 66 normal controls were examined. Radioimmunoassay was used to determine the level of urinary hEGF. Results ① The urinary levels of bEGF in patients with gastric cancer were significantly higher than those in patients with peptic ulcer, chronic gastritis and controls (P <0.01). ② The levels of urinary hEGF in patients with peptic ulcer and chronic gastritis were significantly increased 76.5% of the gastric mucosa accompanied by inter-change or intestinal metaplasia, and with hECF levels increased gastric mucosal intermutation or intestinal metaplasia accounted for an increase. Conclusion The elevated urinary hEGF levels may be related to gastric cancer and gastric precancerous lesions.