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为证实甲状腺激素对中枢神经系统的影响与β受体活动的关系,本文采用内服甲基硫氧嘧啶制作小鼠低甲状腺激素的模型,再用放射配基结合分析法测定小鼠脑β受体最大结合容量(Bmax)和亲和力(KD)的变化。并以助阳药进行实验性治疗。结果表明:脑组织B受体Bmax较对照组显著减少(p<0.001),而β受体亲和力无明显变化;助阳药附子、肉桂以及去甲乌药碱可使降低的β受体结合位点数增多(p<0.01)。揭示甲状腺激素低下可影响小鼠脑β受体数量,用助阳药治疗有效。
To confirm the effect of thyroid hormones on the central nervous system and the relationship between beta-receptor activity, a mouse model of low thyroid hormone was produced using methylthiouracil orally, and then brain β-receptor was measured by radioligand binding assay. Changes in maximum binding capacity (Bmax) and affinity (KD). And to help positive drugs for experimental treatment. The results showed that the B receptor B receptor in the brain tissue was significantly reduced compared with the control group (p<0.001), but there was no significant change in the affinity of the β-receptor; the Astragalus mongholicus, cinnamon, and nor-aurphanine alkaloids could reduce the β-receptor binding site The number of points increased (p<0.01). It was revealed that low thyroid hormones may affect the number of brain β-receptors in mice and that they are effectively treated with adjuvant drugs.