论文部分内容阅读
倍半萜内酯是一类植物次级代谢产物,具有细胞毒性,抗肿瘤及其它方面的药理作用。堆心菊素(helenalin)是从堆心菊Heleniummilrocephalum中分离纯化出来的,对大鼠Walkel 256实体瘤,小鼠Ehrlich腹水瘤具明显的抑制作用。堆心菊素可延长P-388淋巴细胞白血病小鼠的寿命。体内实验证明,堆心菊素明显抑制BDF_1雄性小鼠肝内混合功能氧化酶的活性,并降低微粒体细胞色素P-450(Cyt P-450)和细胞色素b_5的含量。堆心菊素对体外小鼠肝混合功能氧化酶系统有明显的
Sesquiterpene lactones are a class of plant secondary metabolites with cytotoxicity, anti-tumor and other pharmacological effects. Helenalin (helenalin) was isolated and purified from Helenium milrocephalum, and it has obvious inhibitory effect on rat Walkel 256 solid tumor and mouse Ehrlich ascites tumor. Daixin can prolong the life of P-388 lymphocytic leukemia mice. In vivo experiments showed that dacrycin significantly inhibited the activity of mixed-function oxidase in the liver of BDF-1 male mice and decreased the content of cytochrome P-450 (cytochrome P-450) and cytochrome b_5. Dexanthin has obvious effects on mouse liver mixed function oxidase system in vitro