目的　研究大鼠缺血性脑损伤后神经细胞黏附分子的表达对神经可塑性的影响。方法　Wistar大鼠 2 6只 ,分为空白对照组 (n =3)、假手术组 (n =3)和损伤组 (n =2 0 )。对损伤组大鼠 ,使用线栓模型造成右侧大脑中动脉阻断 (MCAO)。再灌 1d(n =5)、2d(n =5)、3d(n =5)和 7d(n =5) ,用免疫组织化学的方法 ,测定脑片神经细胞黏附分子的表达。结果　损伤组 4个时间点颞叶皮质都有神经细胞黏附分子表达的增加 ,以术后 2d、3d明显 ,7d仍有较大量的表达。结论　在短暂缺血性脑损伤后 ,神经细胞黏附分子表达的增加可能与神经可塑性有关 Objective To investigate the effect of neural cell adhesion molecule expression on neuroplasticity after ischemic brain injury in rats. Methods Twenty - six Wistar rats were divided into blank control group (n = 3), sham operation group (n = 3) and injury group (n = 20). Right-sided middle cerebral artery occlusion (MCAO) was induced in a lesion group using a thrombus model. Immunohistochemistry was used to determine the expression of neural cell adhesion molecules on the 1st day after reperfusion (n = 5), 2d (n = 5), 3d (n = 5) and 7d (n = 5) Results At 4 time points, the expression of neural cell adhesion molecules increased in the temporal cortex, which was obvious at 2 days and 3 days after operation. Conclusions After transient ischemic brain injury, the increase of neural cell adhesion molecule expression may be related to neural plasticity