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目的：探讨直肠癌根治术中动脉灌注化疗的临床意义。方法：灌注组３２例，术中经直肠上动脉灌注氟脲嘧啶（５Ｆｕ）和丝裂霉素（ＭＭＣ）；对照组２０例仅作常规手术。统计两组伤口感染、裂开、吻合口瘘和造瘘口坏死回缩的发生率及手术前后ＷＢＣ、ＲＢＣ、ＢＰＣ、ＡＬＴ和ＢＵＮ的变化。结果：两组均无腹部切口感染、裂开，无吻合口瘘和造瘘口坏死；会阴切口感染率灌注组和对照组分别为１８．２％和２０％；ＷＢＣ、ＲＢＣ、ＢＰＣ、ＡＬＴ、ＢＵＮ灌注组手术前和对照组差异均无显著性（Ｐ＞０．０５）。结论：术中动脉灌注化疗无严重毒副作用，不增加术后并发症，是直肠癌有效的辅助治疗措施。
Objective: To investigate the clinical significance of intra-arterial infusion chemotherapy for radical rectal cancer. METHODS: In the perfusion group, 32 patients were treated with 5-fluorouracil (5-Fu) and mitomycin C (MMC) via supra-rectal artery. In the control group, only 20 cases were performed routinely. The incidences of wound infections, dehiscences, anastomotic fistulas, and stoma fistula necrosis and retraction were recorded and the changes of WBC, RBC, BPC, ALT, and BUN before and after surgery were counted. Results: There was no abdominal incision infection, dehiscence, no anastomotic leakage and fistula necrosis in the two groups. Perineal incision infection rate was 18.2% in the perfusion group and 20% in the control group; WBC, RBC, BPC, ALT, There was no significant difference between the BUN perfusion group before operation and the control group (P>0.05). Conclusion: Intraoperative arterial infusion chemotherapy has no serious side effects and does not increase postoperative complications. It is an effective adjuvant treatment for rectal cancer.