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75例可切除直肠癌随机分成两组,治疗组38例,术前两周经股动脉插管肠系膜下动脉灌注化疗(FAM联合方案);临床资料相似的37例作为对照组。治疗组临床症状缓解率达92.1％,肿瘤缩小或变活动者占60.5％;治疗组和对照组的手术切除率相似,分别为100％和94.3％,根治性切除率治疗组(86.8％)高于对照组(67.6％),P<0.05,切除术后两年内复发率对照组(17.14％)明显高于治疗组(2.63％),P<0.05,根治性切除术后5生存率治疗组(75.8％)高于对照组(48.0％),P<0.05。提示可切除直肠癌术前动脉灌注化疗可提高根治性切除率和术后生存率,降低术后复发率。
Seventy-five resectable rectal cancers were randomly divided into two groups: treatment group (38 cases), femoral artery intubation through the inferior mesenteric artery (FAM combined chemotherapy) two weeks before operation, and 37 cases with similar clinical data as the control group. The clinical symptom remission rate was 92.1% in the treatment group, and 60.5% in patients with tumor shrinkage or metamorphosis. The surgical resection rates in the treatment group and control group were similar, being 100% and 94.3%, respectively, and the radical resection rate in the treatment group (86.8%) was high. In the control group (67.6%), P<0.05, the recurrence rate was significantly higher in the control group (17.14%) than in the treatment group (2.63%) within two years after resection, P<0.05, and 5 survival rates after radical resection in the treatment group ( 75.8%) was higher than the control group (48.0%), P<0.05. Resection of rectal cancer preoperative arterial infusion chemotherapy can improve the radical resection rate and postoperative survival rate, reduce postoperative recurrence rate.