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目的 探讨手术前后动脉灌注化疗治疗直肠癌的临床疗效。方法 采用MF化疗方案即MMC + 5 -FU +CF ,对 42例直肠癌患者采用经皮股动脉穿刺和肠系膜下动脉及双侧髂内动脉灌注 ,7～ 10d后手术 ,术后 4～ 6周重复上述治疗 ,共 6个疗程 ,每个疗程 3 0d。结果 术后病理显示原发灶癌细胞坏死率为 85 % ,转移灶坏死率为 80 % ,术中出血量减少 ,手术时间缩短 ,全部病例均获随访 ,随访时间为 6～ 3 6个月 ,除 4例姑息手术平均生存 14个月外 ,其余 3 8例根治术患者均存活 ,生活、工作正常。未发现局部复发及新的转移灶。结论 动脉灌注化疗是有效的直肠癌综合治疗手段之一。
Objective To investigate the clinical effect of arterial infusion chemotherapy for rectal cancer before and after operation. Methods Forty-two patients with rectal cancer underwent percutaneous femoral artery puncture and perfusion of the inferior mesenteric artery and bilateral iliac artery were treated with MF chemotherapy (MMC + 5 -FU + CF). After 7 to 10 days, 4 to 6 weeks after operation Repeat the above treatment, a total of 6 courses, 30d each course. Results The postoperative pathology showed that the necrosis rate of the primary tumor was 85%, the necrosis rate of the metastasis was 80%, the intraoperative blood loss was reduced and the operation time was shortened. All cases were followed up for 6 to 36 months, Except 4 patients who survived for palliative surgery for an average of 14 months, the remaining 38 patients underwent radical surgery living and working normally. No local recurrence and new metastases were found. Conclusion Arterial infusion chemotherapy is one of the effective treatment of rectal cancer.