论文部分内容阅读
目的 探讨p5 3蛋白和增殖细胞核抗原 (PCNA )在胸腺上皮性肿瘤中表达的意义及相互关系。方法 采用S P免疫组化法 ,检测良性胸腺瘤 18例 ,恶性胸腺瘤 16例 ,胸腺癌 16例的 p5 3蛋白与PCNA的表达。 结果 p5 3蛋白和PCNA的Ⅲ～Ⅳ级指数在 3组胸腺上皮性肿瘤中阳性表达率分别为 3 3 .3 % ( 6/18) ,62 .5 % ( 10 /16) ,81.3 % ( 13 /16)和 3 8.9% ( 7/18) ,68.8% ( 11/16) ,81.3 % ( 13 /16) ,(P <0 .0 5 ) ;其阳性表达率与临床分期、淋巴结转移密切相关 (P <0 .0 5 )。结论 p5 3蛋白和PCNA阳性表达率可提示肿瘤恶性程度及其侵袭力和转移能力。
Objective To investigate the significance and relationship of p5 3 protein and proliferating cell nuclear antigen (PCNA) expression in thymus tumor. Methods SP immunohistochemical method was used to detect the expression of p53 protein and PCNA in 18 cases of benign thymoma, 16 cases of malignant thymoma and 16 cases of thymic carcinoma. Results The positive rates of grade Ⅲ ~ Ⅳ of p5 3 protein and PCNA were 33.3% (6/18), 62.5% (10/16), 81.3% (13.3%) in thymus tumor / 16) and 8.99% (7/18), 68.8% (11/16) and 81.3% (13/16) respectively (P <0.05). The positive expression rate was closely related to clinical stage and lymph node metastasis (P <0. 05). Conclusion The positive rates of p5 3 protein and PCNA may indicate the degree of tumor malignancy and its invasion and metastasis.