excitotoxicity相关论文
Excess extracellular glutamate leads to excitotoxicity, which induces neuronal death through the overactivation of N-met......
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This study investigated the neuroprotective activity of red ginseng extract (RGE, Panax ginseng, C.A.Meyer) against kain......
Purposes Convincing data demonstrate that serine racemase(SR)and its product,D-serine contribute to excitotoxicity.A lin......
Trans-Cinnamaldehyde Improves Memory Impairment by Inhibiting Neuroinflammation and Excitotoxicity F
Objective: To investigate the effects of TCA on neuroinflammation and excitotoxicity induced by global cerebral ischemia......
Cytosolic phospholipase A2alpha mediates electrophysiologic responses of hippocampal pyramidal neuro
The arachidonic acid-generating enzyme cPLA2aplha has been implicated in the progression of excitotoxic neuronal injury.......
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The progressive loss of cognitive function is a debilitating complication in individuals aging with HIV-1-infection.The ......
The effects of ANEPⅢ, a new recombinant neurotoxic peptide, on behavior and brain neuronal activity in animal studies h......
p53 induction contributes to excitotoxic neuronal death in rat striatum through apoptotic and autoph
The present study sought to investigate mechanisms by which p53 induction contributes to excitotoxic neuronal injury.Rat......
The aryl hydrocarbon receptor (AhR) is a ligand-activated basic helix-loop-helix/Per-Arnt-Sim (bHLH/PAS) transcription f......
Ischemic stroke is a dominant health problem with extremely high rates of mortality and disability.The mainmechanism......
Achyranthes bidentata polypeptides prevent apoptosis by inhibiting the glutamate current in cultured
Glutamate-induced excitotoxicity plays a critical role in the neurological impairment caused by middle cerebral artery o......
目的 研究阿魏酸钠(SF)腹腔注射对妊娠晚期母小鼠谷氨酸单钠(MSG)灌胃诱导的仔鼠兴奋性毒性神经损伤修复的影响.方法 将妊娠17d小......
Potent protection of Danshensu(β-3,4-dihydroxyphenyl-lactic acid)against excitotoxic effects of mate
Recent studies have demonstrated that ferulic acid[3-(4-hydroxy-3-methoxyphenyl)-2-propenoic acid]and sodium ferulate pr......
Involvement of mitogen-activated protein kinase pathways in N-methyl-D-aspartate-induced excitotoxic
Previous studies have shown that mitogen-activated protein kinase (MAPK) signaling pathways are involved in N-methyl-D-a......
Running is believed to be beneficial for human health. Many studies have focused on the neuroprotective effects of volun......
Aim: To investigate neuropeptide Y (NPY) expression in mouse hippocampus within early stages of kainic acid (KA) treatme......
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,Molecular mechanisms of excitotoxicity and their relevance to pathogenesis of neurodegenerative dis
A pivotal role for excitotoxicity in neurodegenerative diseases is gaining increasingly more acceptance, but the underly......
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,Asiatic acid, a pentacyclic triterpene in Centella asiatica, attenuates glutamate-induced cognitive
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Glutamate-induced neuronal damage is mainly caused by overactivation of N-methyl-D-aspartate (NMDA) receptors.Conversely......
,Neuroprotective effect of deferoxamine on N-methyl-D-aspartate-induced excitotoxicity in RGC-5 cell
Many N-methyI-D-aspartate (NMDA) receptor antagonists have been used to treat neurodegenerative diseases induced by glut......
Nafamostat mesylate, an apparent soi-disant panacea of sorts, is widely used to anticoagulate patients undergoing hemodi......
目的研究藁苯内酯(LIG)对由神经兴奋性毒素鹅膏蕈氨酸(IBO)诱导的神经行为学缺陷和神经病理学改变的影响。方法将IBO注入大鼠的基......
Potent protection of Danshensu(β-3,4-dihydroxyphenyl-lactic acid)against excitotoxic effects of mate
Recent studies have demonstrated that ferulic acid[3-(4-hydroxy-3-methoxyphenyl)-2-propenoic acid]and sodium ferulate pr......
Involvement of mitogen-activated protein kinase pathways in N-methyl-D-aspartate-induced excitotoxic
Previous studies have shown that mitogen-activated protein kinase (MAPK) signaling pathways are involved in N-methyl-D-a......
Basic fibroblast growth factor protects auditory neurons and hair cells from noise exposure and glut
The purpose of the present study was to determine protectivie effects of basic fibroblast growth factor (bFGF) on cochle......
目的 观察不同剂量氯胺酮对喹呆酸(QA)诱导的亨廷顿病(HD)大鼠纹状体损伤的保护作用.方法 将30只雌性SD大鼠随机分为3组,均予注射Q......
The synapse is an incredibly specialized structure that allows for the coordinated communication of information from one......
目的研究桂利嗪（Cin）对兴奋毒喹啉酸（QA）损伤的海马神经元是否有保护作用，并研究其相关机制，方法采用海马神经元原代培养，检测培养神经元......
NMDA(N-甲基-D-天冬氨酸)受体在缺血性脑卒中所致兴奋性神经元死亡中起重要作用,但NMDAR阻滞剂在临床上一直未能取得理想效果。相......
Nafamostat mesylate,an apparent soi-disant panacea of sorts,is widely used to anticoagulate patients undergoing hemodial......
目的兴奋毒性是导致中枢神经元死亡的主要因素之一。为此,本实验旨在形态学探察证实纹状体不同类型中间神经元对兴奋毒性损害因素......
兴奋性氨基酸广泛分布于中枢神经系统，参与多种生理过程包括学习，记忆和伤害感受等。然而，ＥＡＡｓ受 过度兴奋却可引发一系列细胞事件，最终导......
目的 为明确谷氨酸作为一兴奋性氨基酸对中枢神经系统兼有兴奋性和毒性作用的机理。方法 实验选择具有较多ＮＭＤＡ受体的海马作为研究对......
目的：利用原代培养的海马神经细胞，研究人参皂甙Rb3对谷氨酸兴奋性神经毒性的保护作用及有关机制。方法：采用原代培养的胚胎大鼠海马......
目的：研究三七总皂甙（ＰＮＳ）对神经细胞的保护作用。方法：采用原代培养的大鼠大脑皮层神经细胞，观察谷氨酸，缺氧５ｈ再给氧不同时间（０，３，２４ｈ）对细胞的影响以......
目的研究粉防己碱(Tet)对喹啉酸(QA)致大鼠拟痴呆模型学习记忆障碍的改善作用和脑保护作用.方法向大鼠双侧海马CA1区微量注射QA制......
目的：观察谷氨酸诱导海马神经元兴奋毒性损伤中神经营养因子受体p75（p75 neurotrophin receptor,p75NTR）表达水平的变化。方法：建立谷......
目的观察还原型谷胱甘肽(reduced glutathione,GSH)与N-乙酰半胱氨酸(N-Acetylcysteine,NNAC)对不同浓度谷氨酸(glutamate,Glu)诱......
目的 探索应用海人酸在C57BL／6小鼠建立慢性进行性神经退行性病变的新的动物模型。方法 小剂量（3mg／kg体重）海人酸经鼻滴入C57BL／6小鼠，......
兴奋性毒性是最早发现并被广泛认可的脑缺血卒中后损伤的分子机制之一,当大脑处于缺血缺氧状态,由于代谢障碍,导致兴奋性神经递质......
近年来随着对青光眼性视神经病变机制的深入研究,已证实兴奋性氨基酸与青光眼视网膜神经节细胞凋亡密切相关.21世纪青光眼的治疗模......
目的探讨谷氨酸(Glu)对体外培养的大鼠皮层神经细胞作用的量效关系及其毒性损害作用.方法原代培养新生SD大鼠(1 d)大脑皮层神经细......
目的研究不同剂量锰对大鼠纹状体谷氨酰胺合成酶（GS）、谷氨酰胺酶（PAG）和脑皮质琥珀酸脱氢酶（SDH）、钠钾三磷酸腺苷酶（Na^＋-K^＋-ATPase）活性......
目的主要观察母鼠经口给予谷氨酸单钠ig对仔鼠大脑皮层和海马神经元Bax和Bcl-2表达的改变,探讨谷氨酸的兴奋毒性作用;并观察鼠大脑......
兴奋性氨基酸受体的过度活化会导致神经元的兴奋性死亡,该过程与细胞内钙离子([Ca2+]i)稳态失调密切相关。谷氨酸兴奋毒性参与许多......
目的：研究银杏叶提取物（ginkgo biloba extract，GBE）抗兴奋毒性作用及其与胆固醇途径相关性。方法：建立谷氨酸（glutamate，Glu）兴奋毒性模型......
