neurodegeneration相关论文
Distinct Rab7-related Endosomal–Autophagic–Lysosomal Dysregulation Observed in Cortex and Hippocampu
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New insights into Wnt signaling alterations in amyotrophic lateral sclerosis: a potential therapeuti
Amyotrophic lateral sclerosis is a fatal neurodegenerative disorder characterized by upper and lower motor neuron degene......
Neuroinflammation and oxidative stress act in concert to promote neurodegeneration in the diabetic r
Diabetes is a lifelong disease characterized by glucose metabolic imbalance, in which low insulin levels or impaired ins......
Worldwide stroke is increasing in parallel with modernization, changes in lifestyle, and the growing elderly population.......
Stem cells in neuroinjury and neurodegenerative disorders：challenges and future neurotherapeutic pro
The prevalence of neurodegenerative diseases and neural injury disorders is increasing world-wide. Research is now focus......
Amyloid precursor-like protein 2 C-terminal fragments upregulateS100A9 gene and protein expression i
The murine microglial cell line BV2 has neuroprotective effects, but is toxic to neurons by secret-ing inlfammatory cyto......
The accumulation of myelin debris may be a major contributor to the inlfammatory response after diffuse axonal injury. I......
Effects of dizocipine maleate on mitochondrial ultramicrostructure in neurons following traumatic br
BACKGROUND: The effects of N-methyl-D-aspartic acid (NMDA) receptor antagonist on neurodegeneration in the immature brai......
Infantile-onset spinal muscular atrophy is the quintessential example of a disorder characterized by a predominantly neu......
Neuroprotective and anti-inflammatory effects of a therapy combining agonists of nicotinic α7 and σ1
To date there is no treatment able to stop or slow down the loss of dopaminergic neurons that characterizes Parkinson’s......
The canonical Wnt/β-catenin signaling pathway has been shown to play a major role during embryonic development and matu......
Efficacy of short-term multidisciplinary intensive rehabilitation in patients with different Parkins
Parkinson’s disease (PD) can be classified into three motor-based subtypes: postural instability/gait difficulty (PIGD)......
背景 术后认知功能障碍(postoperative cognitive dysfunction,POCD)是麻醉手术后常见的神经系统并发症,尤其在老年人多见.脑内铁......
Effects of dizocipine maleate on mitochondrial ultramicrostructure in neurons following traumatic br
BACKGROUND: The effects of N-methyl-D-aspartic acid (NMDA) receptor antagonist on neurodegeneration in the immature brai......
Amyloid precursor-like protein 2 C-terminal fragments upregulateS100A9 gene and protein expression i
The murine microglial cell line BV2 has neuroprotective effects, but is toxic to neurons by secret-ing inlfammatory cyto......
The accumulation of myelin debris may be a major contributor to the inflammatory response after diffuse axonal injury. I......
Type 2 diabetes is a risk factor for Alzheimer’s disease and Parkinson’s disease. Insulin signaling in the brains of p......
烟酰胺腺嘌呤二核苷酸(NAD+)是生物化学反应的重要介质,作为辅酶参与氧化还原反应,也可以作为底物参与分子信号传递.NAD+在细胞内......
Innate Immunity and Neuroinflammation in the CNS: The Role of Microglia in Toll-Like Receptor-Mediat
小胶质细胞是中枢神经系统内的内源性免疫细胞,在中枢神经系统的固有免疫反应中扮演关键的角色,其主要作用是早期控制感染及激活适......
The VCP-Ufd1-Npl4 complex regulates proteasomal processing within cells by delivering ubiquitinated proteins to the prot......
为探究吕家坨井田地质构造格局,根据钻孔勘探资料,采用分形理论和趋势面分析方法,研究了井田7......
Aluminium-induced acute neurotoxicity in rats:Treatment with aqueous extract of Arthrophytum (Hammad
为探究吕家坨井田地质构造格局,根据钻孔勘探资料,采用分形理论和趋势面分析方法,研究了井田7......
Regional gray matter atrophy and neuropsychologcal problems in relapsing-remitting multiple sclerosi
In multiple sclerosis, gray matter atrophy is extensive, and cognitive deficits and mood disorders are frequently encoun......
Characterization of hippocampal Cajal-Retzius cells during development in a mouse model of Alzheimer
Cajal-Retzius cells are reelin-secreting neurons in the marginal zone of the neocortex and hip-pocampus. The aim of this......
In this study, we established cell models for Parkinson’s disease using rotenone. An RNA interfer-ence vector targeting......
Effects of naringin, a lfavanone glycoside in grapefruits and citrus fruits, on the nigrostriatal do
Recently, we have demonstrated the ability of naringin, a well-known flavanone glycoside of grapefruits and citrus fruit......
Treating Alzheimer’s disease withYizhijiannao granules by regulating expression of multiple proteins
Yizhijiannao granules have been shown to improve cognitive function in Alzheimer’s disease patients. The present study ......
糖尿病视网膜病变是糖尿病常见的并发症,作为微血管病变被广泛报道。研究发现视网膜神经元退行性病变在糖尿病视网膜病变早期已经......
目的 比较糖原合酶激酶3β（glycogen synthase kinase-3β,GSK3β）在正常成年、老年及β淀粉样蛋白（amy-loid beta,Aβ）诱导的神经退行......
糖尿病视网膜病变是人类最主要的致盲原因之一．其发病机制目前尚不清楚。经典理论认为最基本的病理改变为微血管改变。但是近年来的......
目的观察美洛昔康对慢性铝过负荷致神经元退变大鼠脑内金属离子含量的影响。方法给予Wistar大鼠葡萄糖酸铝（Al3＋200mg／ks）灌胃，1次／天，每......
目的观察慢性铝过负荷致神经元退变大鼠海马金属离子含量的变化。方法葡萄糖酸铝（A l3＋200 mg/kg）灌胃给予Wistar大鼠,1次/d,每周连续......
Tau蛋白的功能,现有的研究结果已经比较清晰,涉及多种胞内异常,包括自噬、轴质运输、神经极性的紊乱,以及胞质Tau蛋白分泌到胞外所......
龟脑防御缺氧和再供氧伤害的过程可能与龟类的长寿相关，研究表明龟体内有特别的保护各种离子通道和受体功能的机制，龟脑在缺氧条件下......
以Balb/c nih npc-1小鼠模型为对象,使用免疫组织化学和免疫印迹技术来研究cdk4/cyclin D1/Rb2通路的激活与神经元神经丝蛋白的过......
目的 利用分子克隆接术在愿核细胞中表达α-共核蛋白（SNCP），并制备免多克隆抗体。方法 从人神母经细胞SH-SY5Y细胞中提取总RNA，逆转录......
目的探讨脑缺血/再灌注（I/R）致神经元退行性变所涉及的自由基和SOD2表达的时程变化及其相互关系。方法抽取并回输约40%总血量加双侧......
目的:探讨外源性谷氨酸对新生鼠脑细胞的兴奋毒性作用.方法:新生7天SD大鼠,背部皮下注射单钠谷氨酸(MSG)2 mg/g,在2 h、6～8 h、24～28......
