Pyrimidine相关论文
Novel 2,4-Diarylaminopyrimidine Derivatives Containing Pyridine Moiety:Design,Synthesis,Crystal Stru
A series of 2,4-diarylaminopyrimidine derivatives containing pyridine structure were designed and synthesized.The crysta......
Pyrimidines play an important role in the drug discovery process,and have considerable pharmacological and chemical sign......
Angiogenesis has been demonstrated to be a basic prerequisite for sustainable growth and proliferation of tumor[1],the l......
Lysine specific demethylase 1(LSD1)plays an important role in the epigenetic control of gene expression and it has been ......
Design and synthesis of novel 2-aryl-3-benzyloxy-5-chloro-pyrimidine derivatives as anaplastic lymph
Anaplastic lymphoma kinase(ALK)is a receptor tyrosine kinase(RTK)belonging to the insulin receptor superfamily....
Brutions tyrosine kinase(BTK)is a key component of the B-cell receptor signaling pathway which plays a critical role in ......
Design and synthesis of novel compounds consisting of three kinds of nitrogen-containing heterocycli
pyrimidine,benzimidazole and triazole are important classes of heterocyclic compounds that exhibit a broad spectrum of b......
Design and Synthesis of Novel N3,N5-Diaryl-2,3,5-triaminopyridine Derivatives as Anaplastic Lymphoma
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Pyrimidines have gained great therapeutic importance in the field of medicinal chemistry due to their extensively biolog......
<正> The Chinese hamster cell line Wg3-h and human lymphocytes were used as parental cells for the fusion experiment. Th......
Microwave-assisted synthesis of some novel fluorinated pyrazolo[3,4-d]pyrimidine derivatives contain
A facile microwave-assisted procedure for synthesis of novel fluorinated pyrazolo[3,4-d]pyrimidine derivatives containin......
Synthesis and Crystal Structure of 3-(4-Chlorophenyl)-8-cyano-2-(di-isopropylamino)-5-methyl-7-(meth
The crystal structure of the new title compound 3-(4-chlorophenyl)-8-cyano-2-(di-iso-propylamino)-5-methyl-7-(methylthio......
Sulfonylurea herbicides have been applied worldwide in agriculture. Some sulfonylurea residues might exist in soil longe......
Recombinant Escherichia coli pUDP,which overexpressed uridine phosphorylase(UPase),was constructed.0.5 mmol·L 1lactose ......
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Urea is the degradation product of a wide range of nitrogen containing biomolecules.In mammals,urea is excreted.Many pla......
Distereoselective one-pot synthesis of pyrimidopyrimidines using sulfated tin oxide as a reusable ca
The Biginelli-type compounds 4,5,8a-triarylhexahydropyrimido[4,5-d]pyrimidine-2,7(1H,3H)-diones were synthesized by a on......
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This letter describes a simple and efficient synthesis of 3-(cyclohexylamino)-7-hydroxy-2-arylimidazo[1,2-c]pyrimidin-5(......
Synthesis,spectroscopic characterization,DNA cleavage and antibacterial studies of a novel tridentat
A novel potential tridentate Schiff base was prepared by condensing equimolar quantities of 2-hydroxyacetophenone and 2-......
Theoretical characterization of electronic structures and properties of C-F···H-C pseudohydrogen bon
The weak intermolecular interactions between 2-F-tetrahydrofuran and imidazole, pyrimidine, adenine, and guanine were st......
One-pot synthesis of novel pyrido[2,3-d]pyrimidines using HAp-encapsulated-γ-Fe_2O_3 supported sulfo
Novel pyrido[2,3-d]pyrimidine derivatives were synthesized through a one-pot three-component approach using HAp-encapsul......
Synthesis, Crystal Structure and Antiproliferative Activity of 2-(((5-(((5,7-Dimethyl-[1,2,4]triazol
The novel crystal of the title compound 2-(((5-(((5,7-dimethyl-[1,2,4]triazolo-[1, 5-a]-pyrimidin-2-yl)thio)methyl)-4-ph......
Ultrasound-assisted synthesis and preliminary bioactivity of novel 2H-1,2,4-thiadiazolo[2,3-a]pyrimi
Eight novel 5,7-disubstituted-2-{5-methyl-3-(4-trifluoromethylphenyl)isoxazol-4-ylcarbonylimino}-2H-1,2,4-thiadiazolo[2,......
A facile and efficient approach was developed to access 5,7-disubstitued thiazolo[5,4-d]pyrimidine-4,6(5H,7H)-diones thr......
A series of 2,6-disubstituted-4-morpholinothieno[3,2-d]pyrimidine derivatives were synthesized and their cytotoxic activ......
Synthesis and antitumor activities of a new series of 4,5-dihydro-1H-thiochromeno[4,3-d]pyrimidine d
A new series of 4,5-dihydro-1H-thiochromeno[4,3-d]pyrimidine derivatives have been designed and synthesized.The antitumo......
Facile synthesis of novel fluorinated thieno[2,3-d]pyrimidine derivatives containing 1,3,4-thiadiazo
A series of novel fluorinated thieno[2,3-d]pyrimidine derivatives incorporating 1,3,4-thiadiazole were synthesized by a ......
3-Amino-2-methoxycarbonylthiophene used as the main raw material,an intermediate(thiofuran siamese) 2,4-dichloro-thieno[......
Synthesis and spectroscopic characterization of novel 2-amino-4,5,6,7-tetrahydro-3H-cyclopenta[d]pyr
2-Aminocyclopenta[d]pyrimidines 3a–c were achieved via a one-pot, three-component reactions of cyclopentanone 1, aromat......
An efficient and high-yielding synthesis of N~2-arylaminopyrimidine-5-carbonitrile derivatives starting from arylamines ......
Direct amination of pyrimidin-2-yl tosylates with aqueous ammonia under metal-free and mild conditio
A metal-free synthesis of pyrimidine functionalized primary amines via direct amination of pyrimidin-2-yl tosylate with ......
Synthesis and biological evaluation of 3-(piperidin-4-yl)isoxazolo[4,5-d]pyrimidine derivatives as n
An efficient synthesis of novel 3-(piperidin-4-yl)isoxazolo[4,5-d]pyrimidine scaffold has been designed and deveopled. A......
Hydrothermal Syntheses, Crystal Structures and Fluorescence of a Copper(I) Polymer and a Salt with H
Based on the building block of 2-phenyl-4,6-di(pyridin-2-yl)pyrimidine(L = C20H14N4), a Cu(I) polymer [(Cu C20H14N4)(Cu ......
Syntheses and Crystal Structures of Two New α-Aminophosphonate Derivatives Containing Thieno[2,3-d]p
Two new α-aminophosphonate derivatives containing thieno[2,3-d]pyrimidine, diethyl(((6-ethyl-2-methyl-4-oxothieno[2,3-d......
Sulfonic acid groups were grafted onto three different types of synthesized magnetic nanoparticles, namely Fe3O4, Fe3O4@......
SYNTHESIS AND CHARACTERIZATION OF BLUE LIGHT-EMITTING POLY(ARYL ETHER)S CONTAINING PYRIMIDINE-INCORP
Novel blue light-emitting poly(aryl ether)s comprising of bipolar oligofluorene pendants as chromophores have been desig......
Three component reactions: An efficient and green synthesis of 3, 4-dihydropyrimidin-2-(1H)-ones and
An environmentally benign aqueous protocol for the synthesis of 3,4-dihydropyrimidin-2-(1H)-ones and thiones promoted by......
An efficient method for the synthesis of novel benzo[b]pyrimido[4’,5’:5,4]thieno[2,3e]-[1,6]naphthyridine-8-one deriva......
An efficient method for the synthesis of novel pyrido[3’’,2’’:4’,5’]thieno[3’,2’:2,3]pyrido [4,5:d][1,3]thiazolo......
A series of camphor-derived thiourea organocatalysts 3a–f were designed and synthesized from(1R,3S)-camphoric acid 1 an......
Two new pleuromutilin derivatives, 14-O-[(4-amino-6-methoxyl-pyrimidine-2-yl)-thioacetyl] mutilin(4) and 14-O-[4-amino-1......
Solvothermal reaction of manganese(II) salt with monosodium 2-sulfoterephthalate(2-NaH_2stp) and two multi-pyridine N-co......
An Efficient Novel Synthesis of 14-O-[(4-Amino-6-hydroxy-pyrimidine-2-yl)thioacetyl] Mutilin and the
The title structure of 14-O-[(4-amino-6-hydroxy-pyrimidine-2-yl)thioacetyl] mutilin, C_(26)H_(47)N_3O_5S, has been synth......
A domino desulfitative coupling and decarboxylative coupling of 3,4-dihydropyrimidine-2-thiones with
A novel and general carbon-nitrogen and carbon-carbon cross-coupling reaction between 3,4-dihydropyrimidine-2-thiones an......
Crystal Structure and Theoretical Energy Gap of 2-(2-((4-(Pyridin-2-yl)pyrimidin-2-yl)disulfanyl)pyr
The crystal structure of 2-(2-((4-(pyridin-2-yl)pyrimidin-2-yl)disulfanyl)pyrimidin-4-yl)pyridinium hexafluorophosphate ......
制备了碱性离子液体1,1’-(丁烷-1,4-二基)双(1,4-二氮杂二环[2.2.2]辛烷-1-ium)羟化物,并采用红外光谱、~1H核磁共振谱和pH值分析......
Discovery and synthesis of N~2,N~4-substitued-cycloalkyl[d]pyrimidine-2,4-diamine analogs: The first
A series of novel, cycloalkyl-modified pazopanib analogs 2 and 3 were designed and synthesized. Their kinase modulatory ......
