Sulfonylurea相关论文
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Efffect of addition of low-dose rosiglitazone to sulphonylurea therapy on glycemic control in type 2
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Objective:To investigate the modulatory effects of bitter gourd extract on the insulin signaling pathway in the liver an......
目的:主要探讨胰岛素强化治疗对2型糖尿病磺脲类继发失效患者的疗效.方法:磺脲类继发失效患者21例.停用原口服药后予以胰岛素强化......
Objective: To investigate the modulatory effects of bitter gourd extract on the insulin signaling pathway in the liver a......
高粱是重要五大粮食作物之一,因其对很多化学除草剂相当敏感,喷施时需掌握一定的技巧,一般农户不易把握,而培育抗除草剂高粱是重要......
Design, synthesis and SAR study of novel sulfonylurea derivatives containing arylpyrimidine moieties
Acetohydroxyacid synthase (AHAS) was considered as a promising target for antifungal agents. Herein, three series of nov......
本文通过对荣华二采区10...
ATP-sensitive potassium (KATP) channels are ubiquitously expressed on the plasma membrane of cells in multiple organs, i......
,Ligand binding and conformational changes of SUR1 subunit in pancreatic ATP-sensitive potassium cha
ATP.sensitive potassium channels (KATP) are energy sensors on the plasma membrane.By sensing the intracellular ADP/ATP r......
Laboratory simulated dissipation of metsulfuron methyl and chlorimuron ethyl in soils and their resi
Two sulfonylurea herbicides, metsulfuron methyl (Ally 20 WP) and chlorimuron ethyl (Classic 25 WP) were evalu-ated for t......
Rapeseed is a very important oil crop in China;however,its production is challenging due to the absence of effective wee......
Efffect of addition of low-dose rosiglitazone to sulphonylurea therapy on glycemic control in type 2
Objective We designed a multi-center, double-blind, randomized, parallel, with metformin controlled clinical trial to ev......
为探究吕家坨井田地质构造格局,根据钻孔勘探资料,采用分形理论和趋势面分析方法,研究了井田7......
Study on structure-activity relationship of mutation-dependent herbicide resistance acetohydroxyacid
为探究吕家坨井田地质构造格局,根据钻孔勘探资料,采用分形理论和趋势面分析方法,研究了井田7......
为探究吕家坨井田地质构造格局,根据钻孔勘探资料,采用分形理论和趋势面分析方法,研究了井田7......
为探究吕家坨井田地质构造格局,根据钻孔勘探资料,采用分形理论和趋势面分析方法,研究了井田7......
Efffect of addition of low-dose rosiglitazone to sulphonylurea therapy on glycemic control in type 2
Objective We designed a multi-center, double-blind, randomized, parallel, with metformin controlled clinical trial to ev......
Four 4-monosubstituted pyrimidine pyridyl sulfonylureas were synthesized from pyridinesulfonamide and phenyl pyrimidyl-c......
A novel kind of acetohydroxyacid synthase(AHAS) inhibitors, arylsulfonylaminocarbonyl-2-thiohydantoins, was synthesized ......
Monosulfuron-ester is a novel sulfonylurea herbicide with ultra-low dosage. Herein sodium monosulfuron-ester was synthes......
Sulfonylurea herbicides have been widely used because of their low application rates, good crop selectivities and low ma......
Thirteen novel sulfonylureas containing thiadiazole moiety were synthesized in a two-step reaction. Their structures wer......
Suifonylurea herbicides have been applied worldwide in agriculture.Some sulfonylurea residues might exist in soil longer......
BACKGROUND:Sulfonylurea receptor 1(SUR1)and multidrug resistance protein 1(MRP1)are two prominent members of multidrug r......
通过异氰酸酯法合成一系列新型2-乙内酰硫脲衍生物,应用1H NMR、13C NMR、IR测试技术对分子的结构进行了表征;初步测定了化合物的......
合成了９种未见文献报导的磺酰脲化合物，其结构经元素分析、ＩＲ和＾１Ｈ ＮＭＲ表知性研究表明：２－〖（４－甲氨基－６异丙氧基三唪－２－基）氨基甲酰基氨基磺酰基〗苯甲酸......
目的观察胰岛素泵（胰岛素皮下连续脉冲式输注，CSII）对磺脲类药物继发性失效的2型糖尿病患者强化治疗的效果。方法将78例磺脲类药物继......
<正> 磺酰脲类除草剂具有用量低,活性高、选择性好、毒性小的优点。为开发和应用此类除草剂,我们合成了在氮原子上连正丁基的8个新......
Ten N-(4′-substituted pyrimidin-2′-yl)-2-trifluoroacetylaminobenzenesulfonylureas were synthesized. Their structures w......
以2-取代苯酚、氯磺酰异氰酸酯及4-取代嘧啶胺为原料,合成了14种N-(4-取代嘧啶-2-基)-2-取代苯氧基磺酰脲化合物,通过1H NMR、......
将烷氧基和氟原子引入嘧啶环上取代基的碳链中,合成了12种新型单取代嘧啶环的磺酰脲化合物,其结构经1H NMR谱及元素分析确证.油菜......
单嘧磺隆是一种高效、低毒除草剂。详细介绍了单嘧磺隆的理化性质、毒理学、环境行为和残留研究。并对单嘧磺隆及其相关产品在小麦......
以环十二酮（A）为起始原料，经磺化反应制备得到2-氧代环十二烷基磺酸盐B，B经过氯化和胺解反应制备得到2-氧代环十二烷基磺酰胺C，C经过苯......
为筛选新型高效化学杂交剂,更好地利用油菜化学杀雄杂种优势,利用5种磺酰脲类除草剂(烟嘧磺隆、苄嘧磺隆、酰嘧磺隆、苯磺隆和胺苯......
格列美脲是新一代磺酰脲类降糖药，具有高效、长效、副作用小等优点，以乙酰乙酸乙酯为原料，先制得关键中间体３－乙基－４－甲基－３－吡咯啉－２－酮（Ⅳ），然后与......
用比较分子力场分析(CoMFA)方法和比较分子相似性指数分析(CoMSIA)方法对所合成的新磺酰脲类化合物的除草活性进行了较为系统的3D-......
采用Kromasil C18不锈钢柱（250mm×4．6mm i．d.，5μm），以V（甲醇）：V（水）=70：30混合溶剂为流动相（pH用H3PO4调至3.0），流速1．0mL／min，检测波长236nm和......
建立了气相色谱-质谱法测定磺酰脲类除草剂豆磺隆在土壤中的残留量方法,利用豆磺隆的热不稳定性,对其水解产物4-氯-6-甲氧基嘧啶胺......
采用γ-射线辐射诱变技术,日本和中国学者分别从粳稻和籼稻中获得了苯达松敏感致死突变体农林8号m和M8077S。水稻苯达松敏感突变也......
本文对新型稻田除草剂咪唑黄隆的理化性质、剂型、作用方式、生物活性、应用及合成方法予以介绍。......
以2-氨基-4,6-二羟基嘧啶为起始原料,选用高效催化剂A,经二氟甲基化后得到2-氨基-4,6-双(二氟甲氧基)嘧啶(DMAP);DMAP在溶剂B中与......
目的：观察新磺酰脲药物1-{4-[2-（3-乙基-4-甲基-2-氧-3-吡咯啉-1-甲酰胺基）乙基]-苯磺酰基}-3-（1，4-四亚甲基）脲（BGW）刺激SMMC7721细胞对葡......
目的 探讨不同胰岛素治疗磺脲类药物继发性失效的老年糖尿病患者的疗效及对胰岛功能的影响。方法 66例磺脲类药物继发性失效的老年......
Laboratory simulated dissipation of metsulfuron methyl and chlorimuron ethyl in soils and their resi
二 sulfonylurea 除草剂， metsulfuron 甲基(结盟 20 WP ) ；chlorimuron 乙醇(经典著作 25 WP ) 为他们的驱散行为被评估在冲积，沿海......
应用系统构象搜索及分子动力学模拟方法,研究了新型超高效、'对环境友好'的除草剂1-(4-甲基嘧啶-2-基)-3-(2-硝基苯磺酰)......
采用Dock5和Autodock3的组合,从乙酰乳酸合成酶（ALS）的晶体结构出发,对五个磺酰脲分子和三个类磺酰脲分子与ALS的相互作用方式进行了......
