Lenalidomide相关论文
目的:探讨来那度胺联合硼替佐米及地塞米松（RVD）方案治疗新诊断多发性骨髓瘤（newly diagnosed multiple myeloma，NDMM）患者的疗效及安全......
Lenalidomide monotherapy or combination therapy for angioimmunoblastic T-cell lymphoma:5 case report
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Lenalidomide alone or in combination with chemotherapy treatment for subtypes of diffuse large B cel
Objective: Lenalidomide has been shown to produce durable responses in patients with relapsed or refractory diffuse larg......
Impact of Lenalidomide Exposure on Blood Cell Collection for Autotransplants in Persons with POEMS S
目的 基质细胞衍生因子(SDF-1)及其受体CXCR4在造血干细胞的动员过程中控制着造血干细胞(CD34+细胞)由骨髓向外周血的迁移.而在化......
Chemo-free salvage regimen is superior to conventional chemotherapy in patients with relapsed/refrac
Objective Subcutaneous panniculitis-like T-cell lymphoma(SPTCL)is a rare disease entity which predominantly localizes in......
Interim results from ASPIRE, a randomized, open-label,multicenter phase 3 study evaluating carfilzom
Objective: Rd is a reference treatment for patients with RMM.KRd has shown efficacy in a phase 1/2 study in RMM (Wang et......
Efficacy and Safety of Lenalidomide in the Treatment of Multiple Myeloma: A Systematic Review and Me
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目的:探讨来那度胺(LEN)联合替莫唑胺（TMZ）对TMZ耐药性人脑胶质母细胞瘤系U251/TR细胞增殖、侵袭、耐药性及O6-甲基鸟嘌呤-DNA甲基转......
目的评估伊沙佐米、来那度胺、地塞米松（IRd）方案治疗复发/难治多发性骨髓瘤（MM）的疗效及安全性。方法纳入2018年7月至2020年5月于国内......
目的回顾性分析来那度胺联合环磷酰胺、低剂量地塞米松（RCD方案）治疗多发性骨髓瘤的临床疗效及不良反应。方法45例多发性骨髓瘤患者......
1例53岁男性滤泡性淋巴瘤患者因行R-GDP方案(利妥昔单抗＋吉西他滨＋地塞米松；21 d为1个周期)化疗第5天出现药源性肾损伤而终止疗程，14 d......
目的:在中国,复发/难治性多发性骨髓瘤(RRMM)的治疗方案不能满足患者的需求.来那度胺联合低剂量地塞米松可有效治疗白种人RRMM患者......
Mantle cell lymphoma (MCL) accounts for about 6％ of all non-Hodgkin lymphomas,and it is hard to be treated.Lenalidomide,a......
来那度胺是由Celgene公司研发并上市的一种免疫调节药,是医药领域的超级重磅炸弹式药物。本文对来那度胺相关专利申请进行了分析,......
在药物领域中,最有效的保护创新技术的手段无疑是利用专利进行保护。本文从两个著名的无效诉讼案件（阿托伐他汀案和来那度胺案）出发,......
多发性骨髓瘤(MM)的治疗在不断进步,但复发/难治性MM仍是临床上的难题。埃罗妥珠单抗是美国食品和药物管理局批准的第一个针对靶向......
,Salvage therapy with lenalidomide containing regimen for relapsed/refractory Castleman disease: a r
Castleman disease (CD) is an uncommon non-clonal lymphoproliferative disorder with unknown etiology.No standard therapy ......
Efficacy and Safety of Lenalidomide in the Treatment of Multiple Myeloma: A Systematic Review and Me
Background:Lenalidomide has emerged as an important treatment for patients with multiple myeloma (MM).However,its role i......
慢性淋巴细胞白血病(CLL)是一种常见的血液系统恶性疾病,发病的根本原因至今尚未明确.近年来的研究表明肿瘤微环境对于 CLL细胞的......
目的探讨来那度胺对多发性骨髓瘤(MM)患者自体移植造血干细胞采集的影响。方法回顾性分析北部战区总医院血液科2015—2020年采集外......
目的:评价来那度胺联合利妥昔单抗及地塞米松方案治疗难治复发性套细胞淋巴瘤的临床疗效及安全性。方法:回顾性分析25例难治复发性......
目的:利用辐射损伤动物模型,评价基于辐射防护基因集预测化合物的防护作用。方法:C57BL/6J小鼠随机分为辐射对照组、氨磷汀(150 mg......
目的研究雷利度胺对多发性骨髓瘤（MM）细胞KM3细胞凋亡的影响并初步探讨其作用机制。方法用台盼蓝拒染法检测雷利度胺对KM3细胞生长抑......
多发性骨髓瘤（MM）是以浆细胞恶性克隆增殖为特征的一种血液系统恶性疾病，临床上属于难治性疾病。过去的数十年间，随着诱导方案联合自体......
目的观察来那度胺联合利妥昔单抗（R2）的方案治疗复发难治性（R/R）B细胞非霍奇金淋巴瘤（B-NHL）患者的近期疗效和安全性。方法回顾性分析201......
目的 报道2例del(5)恶性血液病的不同治疗过程,通过文献复习探讨不同治疗方式.方法 分别采用雷利度胺及地西他滨为基础的治疗方案,......
目的评价雷利度胺对自体造血干细胞移植（AHSCT）后复发难治性套细胞淋巴瘤的疗效。方法回顾性分析浙江中医药大学附属第一医院血液科......
5号染色体长臂缺失综合征（5q－综合征）是一种造血干细胞疾病，是一种常见类型的骨髓增生异常综合征（MDS），存在于10％～20％的MDS患者中。发病机制......
目的探讨青蒿琥酯联合来那度胺对多发性骨髓瘤耐药（MM.1R）细胞株增殖的影响并分析其作用机制。方法实验设4组,空白对照组只加RPMI 16......
多发性骨髓瘤（MM）以广泛骨破坏而少有新骨形成为特点。过去的10余年中，以沙利度胺和来那度胺为代表的免疫调节药和以硼替佐咪为代表的......
目的：观察雷利度胺（lenalidomide）单药及联合硼替佐米（bortezomib）诱导多发性骨髓瘤（MM）KM3细胞凋亡的作用,并初步探讨其机制。方法：应用台......
目的 通过观察来那度胺对Lewis荷瘤小鼠T淋巴细胞亚群/树突状细胞比例和程序性死亡受体1及其配体（PD1/PD-L1）通路的影响，探讨来那度胺......
来那度胺是一种新型免疫调节药，主要用于治疗多赶性骨髓瘤和骨髓增生异常综合征，一本品为沙利度胺的衍生物，通过相列小的结构修饰，提高......
目的评估含有雷利度胺的联合化疗方案治疗恶性浆细胞肿瘤的临床疗效。方法回顾性分析15例既往接受过治疗的恶性浆细胞肿瘤，13例为多......
目的讨论新基公司瑞复美（来那度胺）RevCare中国的项目设计、实施以及在实施后的前18个月的成果。方法根据中国市场所特有的医疗实践......
目的:探讨雷利度胺联合化疗治疗急性白血病的临床疗效和对VEGF、bFGF表达的影响,分析雷利度胺与白血病疗效的关系。方法:对2013年1......
New antimyeloma drugs in spinal cord infiltration for multiple myeloma. Determination of lenalidomid
A 64-year-old woman with IgA kappa multiple myeloma was treated with thalidomide-dexa- methasone. Due to progression of ......
目的临床观察雷利度胺加干扰素联合改良MP方案治疗老年多发性骨髓瘤对血象变化的影响,及探讨雷利度胺、干扰素等作用机制。方法选......
目的探讨雷利度胺对Molm-13急性单核细胞白血病细胞体外增殖与凋亡的影响。方法以噻唑蓝法检测不同浓度雷利度胺（60、120、180、240......
AIM: To assess the feasibility of the combination of helical tomotherapy(HT) and a concurrent systemic targeted therap......
Adult Langerhans cell histiocytosis and immunomodulatory drugs:Review and analysis of thirty-four ca
Langerhans cell histiocytosis(LCH)is a rare neoplastic disease in dendritic cells.LCH is classified as either a single-s......
We describe a rare case of testicular plasmacytoma first manifesting as a relapse. The patient was initially diagnosed w......
We describe a rare case of testicular plasmacytoma first manifesting as a relapse. The patient was initially diagnosed w......
Multiple myeloma (MM) is a plasma cell neoplasm characterized for its fast evolution and for being practically incurable......
Successful Treatment of Low-Dose Lenalidomide Maintenance Therapy Followed by Second Autologous Peri
Recently, the prognosis of multiple myeloma has been improved by using high-dose chemotherapy followed by autologous per......
Follow-Up Study of a Multiple Myeloma Patient Successfully Treated with Clarithromycin (CAM), Low-Do
Background: Recently, high efficacy of the chemotherapeutic regimen combining clarithromycin (CAM) with lenalidomide (Le......
目的分析来那度胺联合小剂量地塞米松治疗多发性骨髓瘤的效果,阐述联合用药的临床应用意义。方法选取我院收治的多发性骨髓瘤患者3......
