Amyotrophic相关论文
Chemically oligomerizable TDP-43: a novel chemogenetic tool for studying the pathophysiology of amyo
Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease characterized by the progressive loss of ......
TBN improves motor function and prolongs survival in SOD1G93A and TDP-43M337V mouse model of amyotro
OBJECTIVE Amyotrophic lateral sclerosis(ALS)is a fatal neurodegenerative dis⁃ease characterized by progressive loss of ......
Assessment of causal effects of physical activity on neurodegenerative diseases:A Mendelian randomiz
Background:Physical activity has been hypothesized to play a protective role in neurodegenerative diseases.However,effec......
Objective To explore the association between rare UBQLN2 variants and amyotrophic lateral sclerosis(ALS) in Chinese popu......
Histone deacetylase 6 delays motor neuron degeneration by ameliorating the autophagic flux defect in
Amyotrophic lateral sclerosis(ALS) is a fatal neurodegenerative disorder characterized by the selective loss of motor ne......
Dysfunction of autophagy as the pathological mechanism of motor neuron disease based on a patient-sp
Autophagy is the main catabolic pathway in cells for the degradation of impaired proteins and organelles. Accumulating e......
Transplantation of stem cell-derived astrocytes for the treatment of amyotrophic lateral sclerosis a
Neglected for years, astrocytes are now recognized to fulfill and support many, if not all, homeostatic functionsof the ......
Continual discoveries of new genes and unraveling the genetic etiology in amyotrophic lateral sclerosis(ALS)have provide......
血管生成素(angiogenin,ANG)在伤口愈合、月经周期、妊娠、胚胎发育、先天性免疫、细胞应激保护和维持机体稳态等生理病理过程,特......
Genetic linkage analyses, genome-wide association studies of single nucleotide polymorphisms, copy number variation surv......
BACKGROUND: Affected signal convection of synaptophysin on motor neurons may cause injury of motor neurons and then indu......
成人运动神经元疾病(motor neuron disease,MND)和肌萎缩性侧索硬化症(amyotrophic lateralsclerosis,ALS)的发病机理仍不清楚,病......
肌萎缩性脊髓侧索硬化症 ( amyotrophic lateral sclerosis,AL S)是一种致命的神经退化性疾病 ,在 AL S所有的病例中有 5 %～ 10 %是......
目的 :探讨家族性肌萎缩侧索硬化症患者及家系成员铜锌超氧化物歧化酶 (Cu/ Zn SOD)活性和丙二醛 (MDA)含量变化及家族性肌萎缩侧......
Objective: To understand the relationship between Cu,Zn SOD and amyotrophic lateral sclerosis. Methods: The patients wer......
目的 寻找一个具有特殊临床表型的肌萎缩侧索硬化家系的铜、锌超氧化物歧化酶(Cu/Zn superoxide dismutase,SOD1)基因的突变位点.......
Objective: To explore the protective effect of minocycline on the apoptosis of cellular parkinsonism models induced by M......
To further investigate the pathophysiology of amyotrophic lateral sclerosis (A LS), the silent period (SP) evoked by tra......
额颞痴呆(frontotemporal dementia,FTD)是一种隐袭起病、逐渐进展的非Alzheimer型早老性痴呆,其病理特征为额叶和颞叶前部的进行......
FUNCTIONAL MAGNETIC RESONANCE IMAGING STUDY OF THE BRAIN IN PATIENTS WITH AMYOTROPHIC LATERAL SCLERO
Objective To study the activation changes of the brain in patients with amyotrophic lateral sclerosis (ALS) while execut......
肌萎缩侧索硬化(amyotrophic lateral sclerosis,ALS)是一种选择性侵犯上、下运动神经元的进行性致死性神经系统变性疾病,患者多在......
肌萎缩侧索硬化(amyotrophic lateral sclerosis,ALS)是由上下运动神经元进行性退变引起的一种致死性瘫痪性疾病,散发性ALS(SALS)......
肌萎缩侧索硬化症(amyotrophic lateral sclerosis,ALS)是神经科的常见疾病,而同时伴有运动减少、肢体震颤、记忆力减退、认知功能......
Association between vascular endothelial growth factor gene promoter polymorphisms and sporadic amyo
BACKGROUND: Studies have shown that vascular endothelial growth factor (VEGF) genepolymorphisms highly correlate with s......
胶质细胞源性神经营养因子(glial cell line-derived neurotrophic factor,GDNF)是转化生长因子(transforming growth factorβ,TG......
1临床资料男性患者,57岁,因“消瘦、行为异常1年半”于2008年6月1日入院。1年半以来家人发现患者消瘦,以双上肢变细明显,左侧重于......
Proximal-distal motor unit number estimationdynamic changes in patients with amyotrophic lateral scl
BACKGROUND:Amyotrophic lateral sclerosis(ALS) is the most common of all the motor neuron diseases and the absence of a b......
Amyotrophic lateral sclerosis(ALS) is a disorder that involves the degeneration of motor neurons,muscle atrophy,and para......
目的探讨晚期肌萎缩侧索硬化症(amyotrophic lateral sclerosis,ALS)呼吸机辅助通气患者周围神经传导的特点。方法分析3例呼吸机辅......
“渐冻人症”是运动神经元疾病(Motor Neuron Disease,MND)的一种,又称肌萎缩性侧索硬化症(amyotrophic lateralsclerosis,ALS)。......
肌萎缩侧索硬化(amyotrophic lateral sclerosis,ALS)最显著的病理改变是选择性的运动神经元损害。最近研究表明,运动神经元的缺失......
Changes in somatosensory evoked potentials elicited by stimulation of upper-limb and lower-limb nerv
This study observed the changes in somatosensory evoked potentials between patients with amyotrophic lateral sclerosis (......
Screening proteins that interact with mutant superoxide dismutase 1 from familial amyotrophic latera
The present study screened a human fetal brain cDNA library to find the proteins that interact with mutant superoxide di......
It has been suggested that protein misfolding and aggregation contribute significantly to the development of neurodegene......
肌萎缩侧索硬化(amyotrophic lateral sclerosis,ALS)是一种少见的神经系统变性疾病,以运动神经元的变性为特征,其中80%～90%的ALS患......
This editorial addresses the current challenges and future directions in the use of stem cells as an approach for treati......
Neurofilament protein is a component of the mature neuronal cytoskeleton, and it interacts with the zygosome, which is m......
This study aimed to investigate the number of amino methyl isoxazole propionic acid (AMPA) receptors and production of e......
在中枢神经系统中干扰素(interferon,IFN)信号系统的激活通常与炎症相关。但是,在肌萎缩性侧索硬化症(amyotrophic lateral sclero......
美国麻省总医院神经学研究和临床试验小组的Cudkowicz等人于近期报道了一项临床研究结果,称由BiogenIdec公司和Knopp Neuroscience......
肌萎缩侧索硬化(amyotrophic lateral sclerosis,ALS)是运动神经元病(motor neuron disease,MND)的主要类型,主要特征为选择性侵犯......
Pluripotent stem cells, which are capable of differentiating in various species of cells, are hoped to be donor cells in......
Abnormal TAR DNA-binding protein 43 (TDP-43) inclusion bodies can be detected in the degener-ative neurons of amyotrophi......
Abnormal electrocardiogram in a patient with amyotrophic lateral sclerosis mimicking myocardial isch
阜阳市局 ￡4a 局长——_MINtkMMtgj’＃lnH＄B——q.M——D收束志不他只邀狲位J则【科校为先导推动地租工作.B为广为戳民U用凶盼引眯B.......
Neuronal cell death and regeneration in diseases associated with advanced glycation end-products acc
阜阳市局 ￡4a 局长——_MINtkMMtgj’＃lnH＄B——q.M——D收束志不他只邀狲位J则【科校为先导推动地租工作.B为广为戳民U用凶盼引眯B.......
Adenosine monophosphate-activated protein kinase activation enhances embryonic neural stem cell apop
Alterations in embryonic neural stem cells play crucial roles in the pathogenesis of amyotrophic lateral sclerosis. We h......
阜阳市局 ￡4a 局长——_MINtkMMtgj’＃lnH＄B——q.M——D收束志不他只邀狲位J则【科校为先导推动地租工作.B为广为戳民U用凶盼引眯B.......
阜阳市局 ￡4a 局长——_MINtkMMtgj’＃lnH＄B——q.M——D收束志不他只邀狲位J则【科校为先导推动地租工作.B为广为戳民U用凶盼引眯B.......
