背景:脓毒症生存计划建议对脓毒性休克患者的初始复苏时的平均动脉压至少达到65mmHg。然而,比一个血压目标更高或更低的目标是否更有效还是未知。方法:在一项多中心,开放标签试验中,我们随机分配776例脓毒性休克经历复苏与平均动脉压的目标是80~85 mmHg(高目标组)或65至70mmHg(低目标组)。主要终点是28天死亡率。结果:在28天,两组之间的死亡率并无差异, Background: The Sepsis Survival Plan recommends an average arterial pressure of at least 65 mm Hg for initial resuscitation in septic shock patients. However, it is unknown whether a goal higher or lower than a blood pressure goal is more effective. METHODS: In a multicenter, open-label trial, we randomized 776 patients with septic shock to undergo resuscitation with mean arterial pressure of 80-85 mmHg (high target group) or 65-70 mmHg (low target group). The primary endpoint is the 28-day mortality rate. Results: There was no difference in mortality between the two groups at 28 days,