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目的:观察集束化肺康复治疗对中重度稳定期慢性阻塞性肺疾病（COPD）患者的静态肺功能、心肺运动功能、相关炎性因子的影响。方法:选择2017年12月至2018年10月大连大学附属中山医院60例COPD患者（中重度稳定期），按随机数字表法分为对照组和康复组，每组各30例。对照组给予常规内科治疗，康复组除了给予常规内科治疗外，同时给予集束化肺康复治疗。最终观察两组患者治疗前、治疗后3和6个月的肺功能、心肺运动功能、炎性因子的水平。结果:对照组肺功能[第1秒用力呼气容积（FEVn 1）、第1秒用力呼气容积占预计值百分比（FEVn 1%pred）、第1秒用力呼气容积占用力肺活量（FVC）的百分比（FEVn 1/FVC）]、心肺运动功能[峰值运动功率（peak load）、峰值摄氧量（peak VOn 2）、峰值摄氧量占预计值的百分比（peak VOn 2% pred）、千克摄氧量（peak VOn 2/kg）、峰值分钟通气量（peak VE）]，治疗后3、6个月较治疗前未见明显变化（n P>0.05），康复组治疗后3个月较前一阶段未有改善（n P>0.05），但治疗后6个月较治疗前及治疗后3个月均明显改善（n P0.05）。对照组治疗后6个月CRP、IL-6较治疗前及治疗后3个月时均下降[CRP：（5.48 ± 0.91）mg/L比（6.26 ± 0.99）、（6.09 ± 0.97）mg/L，IL-6：（9.17 ± 1.04）ng/L比（10.83 ± 1.79）、（10.29 ± 1.53）ng/L]（n P0.05), the indexes 6 months after treatment were significantly improved compared with those before treatment and 3 months after treatment (n P 0.05); the CRP and IL-6 6 months after treatment were significantly lower than those before treatment and 3 months: (5.48 ± 0.91) mg/L vs. (6.26 ± 0.99) and (6.09 ± 0.97) mg/L, (9.17 ± 1.04) ng/L vs. (10.83 ± 1.79) and (10.29 ± 1.53) ng/L, n P < 0.05. In rehabilitation group, the CRP, IL-6 and TNF-α 3 and 6 months after treatment were significantly lower than previous phase: (5.21 ± 0.87) and (5.67 ± 0.91) mg/L vs. (6.15 ± 0.92) mg/L, (8.56 ± 1.17) and (10.03 ± 1.61) ng/L vs. (11.06 ± 2.01) ng/L, (7.16 ± 1.33) and (8.05 ± 1.62) ng/L vs. (8.97 ± 2.05) ng/L, n P < 0.05. In rehabilitation group, the CRP, IL-6 and TNF-α before and after treatment were negatively correlated with pulmonary function (FEV n 1, FEVn 1% pred and FEVn 1/FVC) and cardiopulmonary exercise function (peak load, peak VOn 2, peak VOn 2% pred, peak VOn 2/kg and peak VE) (n r=- 0.641 to - 0.884, n P < 0.01).n Conclusions:Bundled pulmonary rehabilitation in patients with moderate or severe stable COPD can improve pulmonary function and cardiopulmonary exercise function and reduce inflammatory factors.