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1963年我院内科住院患者中,发现有三例因服合霉素所致中毒性精神病.例一为53岁男性,临床诊断为急性菌痢,在服合霉素(0.5克Q6h)后,24小时(总量2克)发生精神症状,乱说乱讲,幻视幻听,不得安静.出现精神症状后,当即停用合霉素,并给大量维生素B_1及Nicotinamide,同时静脉注入5%葡萄糖盐水,每天2000毫升左右,及适量冬眠灵.经治疗后,上述幻视、幻听持续三天而完全消失.例二为30岁女性,诊断急性菌痢,当服合霉素(0.5克Q6h)治疗,在服药的第4天(总量10
In 1963, there were three inpatients admitted to our hospital and found that three cases of toxic psychosis due to taking partomycin. A case of 53-year-old man was clinically diagnosed as acute bacillary dysentery. After taking clindamycin (0.5g Q6h), 24 Hour (total 2g) mental symptoms, disorderly talk, hallucinations auditory hallucinations, not quiet.After the onset of psychiatric symptoms, immediately stop taking coenzyme, and to a large number of vitamin B_1 and Nicotinamide, while intravenous infusion of 5% glucose Saline, 2000 ml per day or so, and the amount of winter sleep Ling.After treatment, the visual hallucinations, auditory hallucinations continued for three days and completely disappeared.Second, a 30-year-old female, diagnosis of acute bacillary dysentery, when taking tobramycin (0.5 g Q6h ) Treatment, on the fourth day of medication (total 10