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青霉胺是青霉素加水分解而生成的低分子氨基酸,有右和左旋的光学异构体。左旋的副作用大,故临床上用的是右旋青霉胺。青霉胺有与重金属和胱氨酸结合的作用,所以很早以前就开始用于铜代谢异常的肝豆状核变性,胱氨酸尿疾病等的治疗。 1962年,Jaffa提出,右旋青霉胺有消除类风湿因子的作用,1964年有人报告将该药用于治疗RA合并动脉炎的患者,结果类风湿因子的效价降低及临床症状改善。随后,在欧美及日本进行了广泛的临床研究,结果是满意的。如今可以肯定,本药的抗风湿作用是确实的。它与金制剂一样,是使类风湿性关节炎缓解的药物。
Penicillin is a low molecular weight amino acid produced by hydrolysis of penicillin, right and left-handed optical isomers. Side effects of levorotatory, so the clinical use of dextran penicillamine. Penicillamine has a combination of heavy metals and cystine, so long ago for the treatment of hepatolenticular degeneration, cystine urine disease and other disorders of copper metabolism. In 1962, Jaffa proposed dextran penicillamine to eliminate the role of rheumatoid factor, 1964 was reported to be used in the treatment of rheumatoid arthritis in patients with rheumatoid arthritis, the results of reduced potency and improved clinical symptoms. Subsequently, in Europe and the United States and Japan conducted a wide range of clinical studies, the results are satisfactory. Now you can be sure that the drug’s anti-rheumatic effect is real. Like gold, it is a drug that helps to ease rheumatoid arthritis.