干燥综合征(Sicca Syndrome)又称Sj gren氏综合征(简称SS),约在一百年前即有描述,其基本病变为外分泌腺淋巴细胞浸润,导致腺体功能损伤,尤以泪腺和唾液腺受累最为普遍。SS病变还可广泛累及体内多个系统,包括从良性到恶性的淋巴样增殖的病理变化。 SS可以为单独的疾患,称原发性SS,临床表现为干燥性角、结膜炎和口干;还可伴发有类风湿性关节炎或其它结缔组织病,称之为继发性SS。有关SS的病因迄今尚未明了,对其发病因素曾有不同假说。由于SS多见于40岁以上妇女,与闭经有关,因此,曾提出可能为内分泌功能紊乱所致,亦有人提出某些种维 Sickness syndrome (Sicca Syndrome), also known as Sjgren’s syndrome (SS), described about a hundred years ago, the basic lesion is exocrine lymphocyte infiltration, leading to glandular dysfunction, especially in the lacrimal and salivary glands The most common involvement. SS lesions can also extensively involve multiple systems in the body, including pathological changes from benign to malignant lymphoid proliferation. SS can be a separate disorder, said primary SS, clinical manifestations of dry angle, conjunctivitis and dry mouth; may also be associated with rheumatoid arthritis or other connective tissue disease, known as secondary SS. The etiology of SS has not been known so far, and there have been different hypotheses about its pathogenesis. Because SS more common in women over the age of 40, and amenorrhea related, therefore, had proposed may be caused by endocrine disorders, it was also proposed some kinds of dimension