美国弗吉尼亚大学的研究小组改革了一项技术,首次阐明了人2型腺病毒清晰的内部结构。此病毒是引起感冒的多种病毒之一。Jay Brown等人应用的技术称为“离子蚀刻法”,能去除病毒的衣壳(capsid)部分(病毒外壳蛋白),暴露出病毒内部结构,进行电子显微镜检查。为完成这一研究,研究小组使用了氩离子光束。经过适当的能量加速,氩离子打开衣壳的化学键,穿进50—150埃(?)的深度。当打开足够的化学键时,进入的氩离子能逐出病毒表面的小肽。以这种方式可使病毒内部逐渐暴露。小组提供给《J Virol》杂志的一篇文章中说,人2型腺病毒内部有12个大的球状 A research team at the University of Virginia in the United States has reformed a technique that for the first time elucidated the clear internal structure of human type 2 adenovirus. This virus is one of many viruses that cause a cold. The technique used by Jay Brown et al., Known as “ion-etching”, removes the capsid portion of the virus (viral coat protein), exposes the internal structure of the virus and performs electron microscopy. To complete the study, the team used argon ion beams. With proper energy acceleration, the argon ion opens the capsid’s chemical bond and penetrates to a depth of 50-150 Angstroms (?). When enough chemical bonds are turned on, incoming argon ions can dislodge small peptides on the surface of the virus. In this way, the virus can gradually be exposed internally. In an article by J Virol, the group said that human adenovirus type 2 has 12 large globular