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目的 观察艾滋病 (AIDS)患者局部脑血流 (rCBF)的变化。方法 对 5例男性AIDS患者 (IV期 )进行了99Tcm 双半胱乙酯 (ECD)脑血流灌注显像 ,半定量测定rCBF。 16例性别、年龄匹配的健康者作正常对照。结果 1例有痴呆临床表现的AIDS患者存在双侧额、顶、颞叶和基底节及左侧丘脑rCBF低灌注 ,4例无痴呆临床表现的AIDS患者亦出现双侧额、顶叶rCBF低灌注。AIDS组患者双侧额、顶、颞叶、基底节和丘脑以及直回和桥脑rCBF明显低于对照组。结论 AIDS患者存在脑皮层和皮层下rCBF减少
Objective To observe the changes of regional cerebral blood flow (rCBF) in AIDS patients. Methods Cerebral perfusion imaging was performed in 5 male patients with AIDS (stage IV) with 99Tcm ECD. Semi-quantitative determination of rCBF was performed. 16 cases of gender, age-matched healthy people as a normal control. Results One AIDS patient with clinical manifestations of dementia had bilateral frontal, parietal and temporal lobe and basal ganglia and left thalamus rCBF hypoperfusion. Four patients with AIDS-free dementia also showed bilateral frontal and parietal rCBF hypoperfusion . The rCBF of bilateral frontal, parietal and temporal lobes, basal ganglia and thalamus, as well as straight-back and bridge plexus in AIDS group were significantly lower than those in control group. Conclusion There is a decrease in rCBF in cortex and cortex in AIDS patients