论文部分内容阅读
金属纳米颗粒,特别是金和它的双金属纳米颗粒作为强大的绿色催化剂广泛用于有机合成反应中.在一个反应体系中使用2个不同催化剂(如协同催化),在均相催化中是一个很好的策略.然而,这种方法仍在发展中.最近我们发现,金/钯双金属纳米颗粒与路易斯酸的协同催化体系可用于伯胺的N-烷基化:即酰胺与醇之间的氢自转移反应.我们详细报道了路易斯酸对该氢自转移反应的影响.结果表明,所选的路易斯酸不仅影响生成目标产物的反应路径,而且影响生成多个中间体和副产物的反应路径.弱的路易斯酸,如三氟甲磺酸碱土金属盐,非常适合酰胺的N-烷基化反应.
Metallic nanoparticles, in particular gold and its bimetallic nanoparticles, are widely used in organic synthesis reactions as powerful green catalysts.Using two different catalysts (eg synergistic catalysis) in one reaction system, one in homogeneous catalysis However, this method is still under development.We recently discovered that the synergistic catalysis of gold / palladium bimetallic nanoparticles with Lewis acids can be used for the N-alkylation of primary amines: ie between amides and alcohols .We reported in detail on the effect of Lewis acids on the hydrogen transfer reaction.The results show that the Lewis acid selected not only affects the reaction path to the target product but also affects the reactions that generate multiple intermediates and byproducts Weak Lewis acids, such as the alkaline earth metal triflates, are well suited for the N-alkylation of amides.