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选用选择性动脉导管化疗替代口服和静脉注射全身化疗治疗直肠癌根治术后患者56例,靶动脉为肠系膜上动脉,左(右)髂内动脉和肝固有动脉.化疗药物为DDP 60～80mg,5-Fu 1000～1500 mg,MMC 8～10 mg.经过5年以上的随访,结果复发和转移18例,死亡16例,带瘤生存2例,其1、2、3、4、5年的生存率分别为94.6%、85.7%、82.1%、78.6%、71.4%.治疗时无大出血、肠坏死、死亡等严重并发症.结果显示选择性动脉导管化疗可明显提高直肠癌根治术后患者的5年生存率,降低肿瘤的复发和转移率,且副作用少,可替代口服和静脉注射全身化疗.
Selective arterial catheterization was used instead of oral and intravenous systemic chemotherapy in the treatment of 56 patients with rectal cancer after radical surgery. The target artery was superior mesenteric artery, left (right) internal iliac artery, and hepatic proper artery. The chemotherapeutic drug was DDP 60-80 mg. 5-Fu 1000-1500 mg, MMC 8-10 mg. After more than 5 years of follow-up, the results of recurrence and metastasis in 18 cases, 16 deaths, 2 cases with tumor survival, its 1,2,3,4,5 years The survival rates were 94.6%, 85.7%, 82.1%, 78.6%, and 71.4%, respectively. There was no major bleeding, intestinal necrosis, death, and other serious complications during treatment. The results showed that selective arterial catheterization can significantly improve the patients after radical rectal cancer 5-year survival rate, reduce tumor recurrence and metastasis rate, and fewer side effects, can replace oral and intravenous systemic chemotherapy.