This paper describes a flood routing method applied in an ungauged basin, utilizing the Muskingum model with variable parameters of wave travel time K and weight coefficient of discharge x based on the physical characteristics of the river reach and flood, including the reach slope, length, width, and flood discharge. Three formulas for estimating parameters of wide rectangular, triangular, and parabolic cross sections are proposed. The influence of the flood on channel flow routing parameters is taken into account. The HEC-HMS hydrological model and the geospatial hydrologic analysis module HEC-GeoHMS were used to extract channel or watershed characteristics and to divide sub-basins. In addition, the initial and constant-rate method, user synthetic unit hydrograph method, and exponential recession method were used to estimate runoff volumes, the direct runoff hydrograph, and the baseflow hydrograph, respectively. The Muskingum model with variable parameters was then applied in the Louzigou Basin in Henan Province of China,and of the results, the percentages of flood events with a relative error of peak discharge less than 20% and runoff volume less than 10% are both 100%. They also show that the percentages of flood events with coefficients of determination greater than 0.8 are 83.33%, 91.67%, and 87.5%,respectively, for rectangular, triangular, and parabolic cross sections in 24 flood events. Therefore,this method is applicable to ungauged basins.