基质金属蛋白酶的上调可能参与心肌细胞损伤的发生发展过程,以及参与急性肺血栓栓塞相关的肌钙蛋白的降解过程。研究者检查使用强力霉素(doxy-cycline,一种非特异性基质金属蛋白酶抑制剂)预处理是否能保护心肌细胞免受急性肺血栓栓塞相关的损伤。设计:对照动物实验研究。环境:大学研究实验室。实验对象:杂种狗。干预措施:将动物麻醉后,给 Upregulation of matrix metalloproteinases may be involved in the process of cardiomyocyte injury and development, as well as involved in the process of acute pulmonary thromboembolism related to the degradation of troponin. The researchers examined whether pre-treatment with doxy-cycline, a non-specific matrix metalloproteinase inhibitor, protected cardiomyocytes from acute pulmonary embolism-associated damage. Design: Controlled animal experiments. Environment: University Research Laboratory. Experimental subjects: mongrel dogs. Interventions: The animals are anesthetized and given