论文部分内容阅读
目的探讨血小板衍生生长因子受体(PDGFR-α)和表皮生长因子受体(EGFR)与肺腺癌发生发展的关系。方法免疫组化SP法检测PDGFR-α与EGFR在60例肺腺癌原发灶和24例正常支气管黏膜中的表达。结果 PDGFR-α主要在肺腺癌细胞质表达,少数在细胞核表达;EGFR主要表达于肿瘤细胞的细胞膜上,细胞浆中也有表达。二者均在肺腺癌细胞中过度表达(P<0.05)。PDGFR-α的阳性表达率在肺腺癌高分化组明显高于低分化组(P<0.05),而EGFR在肺腺癌高分化组和低分化组中的表达相仿(P>0.05)。结论 PDGFR-α的阳性表达与肺腺癌的分化程度呈正相关,EGFR的阳性表达与肺腺癌的分化程度无相关性。
Objective To investigate the relationship between platelet-derived growth factor receptor (PDGFR-α) and epidermal growth factor receptor (EGFR) and the development of lung adenocarcinoma. Methods Immunohistochemical SP method was used to detect the expression of PDGFR-α and EGFR in 60 cases of primary lung cancer and 24 cases of normal bronchial mucosa. Results PDGFR-α was mainly expressed in the cytoplasm of lung adenocarcinoma, a few in the nucleus; EGFR was mainly expressed in the cell membrane of tumor cells, and was also expressed in cytoplasm. Both were overexpressed in lung adenocarcinoma cells (P <0.05). The positive rate of PDGFR-α in well-differentiated lung adenocarcinoma was significantly higher than that in poorly differentiated lung adenocarcinoma (P <0.05), while the expression of EGFR in well-differentiated and poorly differentiated lung adenocarcinoma was similar (P> 0.05). Conclusion The positive expression of PDGFR-α is positively correlated with the differentiation degree of lung adenocarcinoma. There is no correlation between the positive expression of EGFR and the differentiation degree of lung adenocarcinoma.