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为了研究环孢素(CsA)对糖代谢作用的可能性,将单用CsA治疗的肾移植病人与其他免疫抑制剂治疗的同种病人进行了比较,用作分析CsA对这些病人胰岛素内分泌功能的影响。资料和方法选自1980年～1988年的504例肾移植病人,随机分为3组。Ⅰ组(7例):单用CsA,剂量2～6mg/kg/d;Ⅱ组(7例):CsA剂量同Ⅰ组+维持剂量10 mg/d的甲基强的松龙(MP);Ⅲ组(6例):MP(10mg/d)+维持剂量1～2mg/d的硫唑嘌呤。对照组(7例)为健康人。检测方法:在清晨空腹时,口服75g葡萄糖,行
In order to investigate the possibility of cyclosporin (CsA) on glucose metabolism, renal transplant patients treated with CsA alone were compared with those treated with other immunosuppressants in order to analyze the effect of CsA on insulin endocrine function in these patients influences. Materials and Methods 504 cases of renal transplant patients from 1980 to 1988 were randomly divided into three groups. Group Ⅰ (n = 7) received CsA alone at a dose of 2 to 6 mg / kg / d. Group Ⅱ (n = 7) received CsA at a dose of 10 mg / d of methylprednisolone (MP) Group Ⅲ (6 cases): MP (10mg / d) + maintenance dose of azathioprine 1 ~ 2mg / d. The control group (7 cases) was healthy. Detection: fasting in the morning, oral glucose 75g, OK