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目的：探讨血管紧张素Ⅱ受体１ 拮抗剂（ Ａ Ｔ１ Ａ） 和血管紧张素转换酶抑制剂（ Ａ Ｃ Ｅ Ｉ） 对慢性肾衰（ Ｃ Ｒ Ｆ） 肾功能的影响及可能的机制。 方法：观察氯沙坦和苯那普利对５／６ 肾切除模型大鼠蛋白尿、肌酐清除率（ Ｃｃｒ） 以及肾小球和肾小管细胞凋亡程度等方面的影响。 结果：两药物治疗组在给药１０ 周后对 Ｃ Ｒ Ｆ 大鼠的平均收缩压、 Ｃｃｒ 以及尿蛋白均有明显改善； Ｃ Ｒ Ｆ 大鼠较假手术组其肾小球和肾小管细胞凋亡指数增高（ Ｐ＜ ００１） ，而氯沙坦和苯那普利对此有明显抑制作用，此效应氯沙坦比苯那普利更加显著。 结论： Ａ Ｔ１ Ａ 和 Ａ Ｃ Ｅ Ｉ 可能通过抑制 Ｃ Ｒ Ｆ 时肾实质细胞过度凋亡而产生肾保护效应。
Objective: To investigate the effects of angiotensin Ⅱ receptor antagonist (A T1 A) and angiotensin converting enzyme inhibitor (A C E I) on renal function in chronic renal failure (C R F) and its possible mechanism. Methods: The effects of losartan and benazepril on proteinuria, creatinine clearance (Ccr) and glomerular and tubular cell apoptosis in 5/6 nephrectomized rats were observed. Results: The average systolic blood pressure, Ccr and urinary protein in C R F rats were significantly improved in both groups after 10 weeks of treatment. Compared with sham-operation group, C R F rats showed glomerular and tubular cell apoptosis The index of death increased (P <0 01), while losartan and benazepril significantly inhibited this effect losartan benazepril even more significant. CONCLUSION: A T1 A and A C E I may have renal protective effects by inhibiting excessive apoptosis of renal parenchymal cells during C R F.