论文部分内容阅读
在动物实验的基础上，比较了抗ＡＦＰ单克隆抗体（ｍＡｂ）和抗ＡＦＰ多克隆抗体（ｐＡｂ）两种不同抗体双弹头标记物在肝癌患者体内的生物代谢情况。结果显示，两种抗体标记物的血浆清除半衰期均在２４ｈ左右，ｍＡｂ标记物的清除较ｐＡｂ标记物略慢。尿清除的半衰期，ｍＡｂ标记物约为１２０ｈ，而ｐＡｂ标记物则约为１８ｈ，表明二者的体内生物代谢不同，疗效可能不一。
On the basis of animal experiments, we compared the biological metabolism of anti-AFP monoclonal antibody (mAb) and anti-AFP polyclonal antibody (pAb) bi-warhead markers in patients with liver cancer. The results showed that the plasma half-lives of both antibody labels were around 24 h, and the removal of mAb labels was slightly slower than the pAb label. The half-life of urinary clearance was about 120 h for the mAb and about 18 h for the pAb marker, indicating that the biological metabolism of the two was different and the efficacy might be different.