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局麻药所致的不利反应包括毒性反应、应。变态反应非常少见,它可能与麻药本身或它的附加物有关。一般说来,皮内试验对于估计是否对局麻药过敏是有价值的。然而,一些对局麻药过敏的病人也可出现皮内试验阴性,或皮内试验阴性伴体外淋巴细胞转化试验阳性。也有人提出,粘膜对局麻药的变态反应较皮肤更强烈。本研究的目的是比较有局麻过敏史病人的体内(皮内试验)和体外(淋巴细胞转化)试验。
Adverse reactions caused by local anesthetics include toxic reactions. Allergies are rare and may be related to the anesthetic itself or its addenda. In general, intradermal tests are valuable for assessing whether they are allergic to local anesthetics. However, some patients who are allergic to local anesthetics may also have a negative intradermal test or a negative lymphocyte transformation test in vitro with a negative intradermal test. It has also been suggested that mucous membranes have a stronger allergic reaction to local anesthetics than the skin. The purpose of this study was to compare the in vivo (intradermal test) and in vitro (lymphocyte transformation) tests in patients with a history of allergy to local anesthesia.