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Background To investigate the clinical effect of different drugs injected intra-microcatheter on no-reflow phenomenon during percutaneous coronary interventions (PCI) for acute myocardial infarction (AMI).Methods The study group of 66 patients with no reflow phenomenon form March 2009 to March 2013 during emergency PCI operation,were randomly divided into verapamil group (n=22),tirofiban group (n=22) and nitroglycerin group (n=22).Verapamil,tirofiban and nitroglycerin were injected to distal vascular bed of target vessel through Intro-microcatheter when no-reflow phenomenon occurred.The cases of thrombolysis in myocardial infarction-3 (TIMI-3) flow grade and TIMI myocardial perfusion-3 (TMPG-3) grade at the endpoint of PCI,the times from no-reflow occurred to the first drug injection,the times from no-reflow occurred to restored TIMI-3 blood flow and TMPG-3 perfusion,The times of PCI and X-ray exposure and left ventricular ejection fraction (LVEF) after one week were compared.