Stability of rat models of lfuid percussion-induced traumatic brain injury:comparison of three diffe

来源 :中国神经再生研究(英文版) | 被引量 : 0次 | 上传用户:LH120013
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
Fluid percussion-induced traumatic brain injury models have been widely used in experimental research for years. In an experiment, the stability of impaction is inevitably affected by factors such as the appearance of liquid spikes. Management of impact pressure is a crucial factor that determines the stability of these models, and direction of impact control is another basic ele-ment. To improve experimental stability, we calculated a pressure curve by generating repeated impacts using a lfuid percussion device at different pendulum angles. A stereotactic frame was used to control the direction of impact. We produced stable and reproducible models, including mild, moderate, and severe traumatic brain injury, using the MODEL01-B device at pendulum angles of 6°, 11° and 13°, with corresponding impact force values of 1.0 ± 0.11 atm (101.32 ± 11.16 kPa), 2.6 ± 0.16 atm (263.44 ± 16.21 kPa), and 3.6 ± 0.16 atm (364.77 ± 16.21 kPa), respec-tively. Behavioral tests, hematoxylin-eosin staining, and magnetic resonance imaging revealed that models for different degrees of injury were consistent with the clinical properties of mild, moderate, and severe craniocerebral injuries. Using this method, we established lfuid percussion models for different degrees of injury and stabilized pathological features based on precise power and direction control.
其他文献
期刊
期刊
在临床上有一部分癫痫患者的脑电图检查是正常的,影响诊断.但强烈的肌肉运动,可使血清肌酸激酶(CK)增高[1],对1周内有癫痫发作的30例病人,测定血CK含量.现将结果报告如下.
Alzheimer病(AD)是以进行性记忆和认知功能丧失为临床特征的大脑退行性疾病,其神经病理学特征为神经细胞内神经原纤维缠结(neurofibrillary tangles, NFTs)、神经细胞外老年
期刊
第四军医大学西京医院神经外科主任医师、博士生导师、全军神经外科专业委员会主任委员、副总编辑易声禹教授,因病于2000年1月12日不幸逝世,享年74岁.
Electroacupuncture has therapeutic effects on ischemic brain injury, but its mechanism is still poorly understood. In this study, mice were stimulated by electr
<正>世界卫生组织发布《使用抗逆转录病毒药物治疗和预防艾滋病毒感染指南》,公布了新的艾滋病抗病毒治疗标准。中国疾病预防控制中心性病艾滋病预防控制中心组织国家卫生计
Ischemic edema can alter the structure and permeability of the blood-brain barrier. Recent stud-ies have reported that progesterone reduces cerebral edema after