parkin相关论文
背景：黄芪桂枝五物汤对椎间盘退行性疾病有一定的保护作用。线粒体自噬在调控细胞线粒体损伤和氧化应激中发挥着重要的作用，但黄芪桂......
＜正＞脓毒症是指由感染引起的全身炎症反应综合征，它是严重创（烧）伤、休克、感染及外科大手术患者常见的并发症，进一步发展可导致脓毒性休......
帕金森病（Parkinson’s disease,PD）是第二大神经退行性疾病,现无特效药进行治疗,表现以震颤、僵直和运动障碍为主。锰作为人体必需......
基于PINK1-Parkin信号通路，探讨当归芍药散对链脲佐菌素（streptozocin，STZ）诱导阿尔茨海默病（Alzheimer disease，AD）大鼠模型线粒体自噬影......
目的 阿霉素（doxorubicin, Dox）的临床应用受到其剂量依赖的心脏毒性的限制，本研究拟探究槲皮素（Quercetin, Que）在Dox诱导的细胞毒性中......
目的:研究褪黑素调控PINK1/Parkin通路改善多囊卵巢综合征患者颗粒细胞线粒体损伤的分子机制。方法:Western Blot 检测多囊卵巢综......
目的:自噬是细胞的一种正常生理活动,也可在细胞遭受各种刺激时激活,起到保护细胞或是加重细胞损伤的作用。本课题从细胞水平分别......
肝脏外科手术尚有诸多问题需要解决,例如手术或者术后引起的肝脏缺血再灌注损伤始终是肝脏外科无法回避的问题,如何避免或减少肝脏......
目的:前期研究证实,H9c2心肌细胞再灌注损伤后,自噬水平过度激活,导致细胞凋亡,加重细胞损伤。本实验进一步探讨VDAC1对再灌注损伤......
[目的]观察荷瘤状态下小鼠心肌损伤情况,探讨park2基因编码的E3泛素-蛋白连接酶Parkin介导线粒体自噬在荷瘤小鼠心肌损伤中的作用......
Heart aging is characterized by structural and diastolic dysfunction of the heart.However,there is still no effective dr......
Ablation of Akt2 and AMPKα2 rescues high fat diet-induced obesity and hepatic steatosis through Park
Given the opposing effects of Akt and AMP-activated protein kinase(AMPK)on metabolic homeostasis,this study examined the......
Histone deacetylase inhibitors inhibit cervical cancer growth through Parkin acetylation-mediated mi
Parkin,an E3 ubiquitin ligase,plays a role in maintaining mitochondrial homeostasis through targeting damaged mitochondr......
细胞的死亡有多种形式,包括凋亡、坏死性凋亡、焦亡等,各具有独特的分子特征,发挥着不同的功能.近年来,对各种死亡形式的功能和机......
Parkin作为E3泛素连接酶广泛参与细胞内的代谢活动.Parkin蛋白包含多个功能性结构域,在通过人第10号染色体缺失的磷酸酶及张力蛋白......
目的:NLRP3（NOD-1ike receptor pyrin domain containing three）炎性复合体是固有免疫系统的重要组成部分,能够诱导炎症细胞因子（如IL......
朊病毒病,又称可传播性海绵状脑病（Transmissible spongiform encephalopathies,TSE）,它是一种罕见的、能够引起人类及多种动物脑组......
甘油酰基激酶（acylglycerol kinase,AGK）是一种脂质激酶,它催化磷脂酸和溶血磷脂酸的形成,参与磷脂的合成,也可作为细胞信号分子调节......
PINK1 is a mitochondrial serine/threonine kinase,which protects mitochondria from cellular stress and regulates neuronal......
E3 ligase Nrdp1 increases ischemia induced primary rat cerebral cortical neurons injury via downregu
Neuregulin receptor degradation protein-1(Nrdp1)is an E3 ubiquitin ligase that regulates the proteasomal degradation and......
Parkin ameliorates dopaminergic neurodegeneration induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyr
Mutations in the parkin gene are currently thought to be the most common cause of familial Parkinsonism.Overexpression o......
Parkin-dependent mitophagy induced by acidic postconditioning extends reperfusion window in focal ce
Prompt reperfusion after cerebral ischemia is critical for neuronal survival.Any strategies extend the limited reperfusi......
目的 研究阿霉素(Doxorubicin,DOX)诱导人心室肌细胞(AC16)线粒体毒性,引起线粒体自噬的分子机制.方法 用不同浓度DOX分别处理AC16......
AMPKα-PINK1/parkin-mediated mitophagy involved in human aortic vascular smooth muscle cells prolifer
Vascular smooth muscle cell proliferation is tightly linked to the pathogenesis of vascular proliferative diseases such ......
Disease-causing mutations in parkin protein impair mitochondrial function and enhance neurodegenerat
Mutations in parkin,a ubiquitin ligase,cause early-onset familial Parkinsons disease.There are many reports on the funct......
目的:构建Parkin基因敲除(knock out,KO)小鼠肾虚证动物模型.方法:本研究设置对照组、Parkin KO组、氢化可的松组,观察并记录小鼠......
目的探讨PINK1/Parkin信号通路在脉冲射频（PRF）治疗大鼠带状疱疹后神经痛（PHN）模型中的作用。方法SPF级健康成年雄性SD大鼠32只，体重200......
Objective To investigate the protective effects and mechanism of Chinese herbal compound Tongxinluo Capsule(通心络胶囊,T......
线粒体自噬(mitophagy)属于巨自噬的范畴,即受损线粒体被一种双层膜结构(如粗面内质网的无核糖体附着区脱落的双层膜)包裹后形成自......
Efficient bi-allelic gene knockout and site-specific knock-in mediated by TALENs in pigsabc Publishe
Objective To establish the platform of TALENs mediated gene editing in pigs and produce DJ-1 gene knockout (KO) pigs......
Objective To establish the platform of TALENs mediated gene editing in pigs and produce DJ-1 gene knockout (KO) pigs......
Rab7 and mitochondrial Rab-GAPs govern autophagosome biogenesis through Atg9 assembly during mitopha
Excess mitochondrial stress and/or mitochondrial dysfunction are implicated in the development of neurodegenerative ......
目的探讨β-细辛醚对淀粉样前体蛋白(APP)/早老素1(PS1)小鼠的作用机制及对PINK1/Parkin介导的线粒体自噬的影响。方法将APP/PS1小......
目的:观察线粒体自噬在急性心梗(MI)早期的变化及对1型糖尿病(DM)小鼠心肌急性缺血损伤的影响。方法:将100只健康雄性C57BL/6小鼠......
目的:探讨卡络磺钠是否通过抑制线粒体自噬来减轻脓毒症大鼠的急性肺损伤。方法:将雄性Wistar大鼠随机分为5组:假手术组、脓毒症组......
为探究吕家坨井田地质构造格局,根据钻孔勘探资料,采用分形理论和趋势面分析方法,研究了井田7......
目的:研究PINK1/Parkin通路在肠缺血再灌注(IIR)所致急性肾损伤中的作用。方法:野生型成年雄性C57BL/6J小鼠随机分为假手术组(S组)......
所有细胞中都存在着本底水平的自噬来维持稳态,通常自噬作为一种保护机制可使胁迫状态下(如营养剥夺)的细胞得以存活。然而,近些年......
帕金森病(PD)是一种发病率较高的神经退行性疾病,遗传、环境等多种因素均参与其病理生理过程.在PD致病相关蛋白中,PARK2基因编码的......
目的:研究PINK1-Par-kin介导的线粒体自噬在阿霉素(Doxorubicin,DOX)致人心室肌细胞(AC16)线粒体损伤中的作用。方法:分别用不同浓......
Parkin,又名PARK2,自发现初始便与帕金森病(Parkinson's disease,PD)密切相关.Parkin被认为是一种神经保护性基因.随着对其结构的......
研究背景帕金森病(Parkinson’s Disease,PD)是一种老年神经退行性疾病,其发病率仅次于阿尔茨海默病(Alzheimer’s Disease,AD)。P......
Presenilin(PS)基因突变,包括Presenilin 1(PS1)和Presenilin 2(PS2)突变,是神经退行性疾病--家族性阿兹海默症(Familial Alzheime......
目的:研究多聚谷氨酰胺疾病蛋白Ataxin-3对parkin介导的线粒体自噬的影响。方法:扩增并提取包含目的基因的质粒(Ataxin-3-20Q-EGFP......
