Silibinin相关论文
Synergistic Inhibition of Breast Cancer Metastasis by Silibinin-Loaded Lipid Nanoparticles Containin
Tumor metastasis is the leading came of breast cancer-related mortality and remains to be the principal obstacle for the......
Objective: Silibinin, a major bioactive flavanone derived from the herb milk thistle, has potent anti-inflammatory and a......
This study aimed to investigate whether silibinin could improve the learning and memory, and antioxidant abilities of Al......
In this study we examined the effects of silibinin, a flavonoid derived from the herb milk thistle, on impaired learning......
Brain dysfunction induced by amyloid β25-35 combined with excessive exercise in rats is protected by
Alzheimers disease (AD), a neurodegenerative disease,is seriously threatening the health of the elderly.In recent years,......
The mechanisms of silibinin-induced autophagic and apoptotic death in human fibrosarcoma HT1080 cell
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Behavioral and neurochemical deficits in aging rats with increased neonatal iron intake: silibinin&#
Aging is a critical risk factor for Parkinsons disease.Silibinin,a major flavonoid in Silybum marianum,has been suggeste......
作者研究抗癌药物silibinin对雄激素敏感的前列腺癌细胞系LNCaP的端粒酶活性、前列腺特异抗原 (PSA)及雄激素受体辅助激活因子 前......
目的 评价在无肝损伤易感因素人群中应用水飞蓟宾保肝治疗对预防抗结核药物性肝损伤(druginduced liver injury,DIM)的临床疗效和......
目的探讨水飞蓟宾联合软肝丸治疗血吸虫病肝纤维化的疗效、机制及安全性。方法将200例血吸虫病肝纤维化患者随机分为对照组和治疗......
本文通过对荣华二采区10...
The unending morbidity and mortality that results from cancer, as well as adverse reactions due to chemotherapy and the ......
Combinatorial treatment of curcumin or silibinin with doxorubicin sensitises high-risk neuroblastoma
Aim: Neuroblastoma is a pediatric cancer of the sympathetic nervous system. Using various parameters including stage of ......
,Combinatorial strategies for cancer eradication by silibinin and cytotoxic agents: efficacy and mec
In an effort to develop effective alteative strategies that increase the therapeu-tic efficacy and minimize the systemic......
,Activation of extracellular signal-regulated kinase during silibinin-protected, isoproterenol-induc
Aim: To investigate the mechanism of silibinin-protected isoproterenol-induced apoptosis in rat cardiac myocytes.Methods......
,Silibinin inhibits prostate cancer invasion, motility and migration by suppressing vimentin and MMP
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,Co-delivery of docetaxel and silibinin using pH-sensitive micelles improves therapy of metastatic b
Breast cancer is the most vicious killer for women,and tumor metastasis is one of the leading causes of breast cancer th......
,Targeted delivery of hyaluronic acid nanomicelles to hepatic stellate cells in hepatic fibrosis rat
Hepatic fibrosis is one kind of liver diseases with a high mortality rate and incidence.The activation and proliferation......
我们应用水飞蓟宾(卵磷脂复合物胶囊)对抗结核药物所致的肝功能损害进行预防性治疗,现报道如下. 一、资料与方法 1.临床资料......
Inhibitory effect of silibinin combined with 5-FU treatment on malignant biological behaviors of gas
为探究吕家坨井田地质构造格局,根据钻孔勘探资料,采用分形理论和趋势面分析方法,研究了井田7......
目的比较四种黄酮类物质抗氧化能力和防止晚期糖化终末产物的形成能力.方法通过对黄连素,槲皮素,水飞蓟宾和水飞蓟素四种不同的黄......
目的 对水飞蓟宾治疗对非酒精性脂肪性肝病患者转氨酶影响的文献进行Meta分析,探讨水飞蓟宾对脂肪肝患者的护肝作用。方法 计算机......
目的：探讨血脂康联合水飞蓟宾对脂肪肝患者血脂的影响。方法：将我院208例脂肪肝患者随机分为血脂康对照组（106例）和血脂康联合水飞蓟宾......
目的：观察水飞蓟宾对大鼠肝贮脂细胞ＨＳＣ－Ｔ６增殖和胶原合成的影响，探讨其保护肝脏及抗硬化机制。方法：采用结晶紫染色法测定细胞增殖，＾３Ｈ－脯氨酸掺......
Silibinin induces hepatic stellate cell cycle arrest via enhancing p53/p27 and inhibiting Akt downst
BACKGROUND: Proliferation of hepatic stellate cells(HSCs) plays a pivotal role in the progression of liver fibrosis cons......
研究了多壁碳纳米管修饰电极的制备方法及其对水飞蓟宾的电催化作用。利用循环伏安法和线性扫描法在乙醇-磷酸盐缓冲溶液中（pH：5．56）研......
目的:观察水飞蓟宾(Silbinin)对大鼠酒精性脂肪肝作用及其机制.方法:饮用10%乙醇,加高脂高热量饲料喂饲6周,造成大鼠酒精性脂肪肝......
目的：研究水飞蓟宾在体外对舌癌细胞的作用，并进一步探讨其可能的作用机制。方法：MTT实验测定水飞蓟宾对舌癌细胞系（Tca）的半数抑制浓度......
目的：观察水飞蓟宾对人肝星状细胞LX-2凋亡与α1（I）胶原mRNA表达的影响。方法：人肝星状细胞株LX-2分为对照组与实验组,对照组以体积分......
为了探讨肝龙胶囊联合水飞蓟宾对猪血清诱导的肝纤维化大鼠肝组织工型胶原（Col-I）、基质金属蛋白酶抑制剂1（TIMP-1）基因表达的影响，采用......
目的：研究水飞蓟宾（Silibinin,SB）在体外对人乳头状甲状腺癌细胞株TPC-1增殖的抑制作用。方法：采用CCK-8法观察不同浓度水飞蓟宾对TPC-......
目的：观察药物水飞蓟宾对分离的成年大鼠心肌细胞钙通道阻滞效应。方法：用成年大鼠分离的心肌细胞，以放射性同位素＾４５Ｃａ＾２＋作示踪，通过对经细胞......
瞄准：在肝细胞上调查在试管内效果和 silibinin 的机制癌(HCC ) 细胞生长。方法：人的 HCC 房间线与 silibinin 的不同剂量被对待。HC......
目的研究水飞蓟宾对前列腺癌细胞增殖、凋亡的影响,并探讨其分子生物学机制。方法使用前列腺癌细胞系C4-2和PC-3作为研究对象。采......
目的研究水飞蓟宾缓释凝胶剂的处方和工艺,并研究其体外释放特性。方法建立体外释放率测定方法,并以在1、5、10 h的释放率为综合指......
目的：探讨拉米夫定联合水飞蓟滨对乙型肝炎肝硬化指标变化的影响。方法：将64例乙型肝炎肝硬化患者随机分为治疗组和对照组，治疗最少12......
目的探讨水飞蓟宾抑制缺氧状态下胃癌细胞MGC803细胞的生长增殖的分子机制。方法体外缺氧条件下体外培养胃癌细胞系MGC803,用不同......
目的 研究葛根芩连汤(gegenqinlian decoction，GGQLD)、二甲双胍(mefformin，met)和水飞蓟宾(silibinin，sil)对D-半乳糖(D-galactose，G-......
目的：比较水飞蓟宾固体分散体胶囊与片剂的人体生物利用度。方法：１０名健康男性志愿者随机自身交叉单剂量口服（７７ｍｇ）水飞蓟宾固体分散体胶囊与......
目的：制备了水飞蓟宾的固体分散体，并检测其体外溶解度及溶出速度。方法：选择尿素、聚乙烯吡咯烷酮（ＰＶＰ）、泊洛沙姆１８８等３种载体，用熔融法和共沉......
目的：探讨水飞蓟宾对人肝癌细胞HepG2的杀伤作用及其机制。方法不同浓度水飞蓟宾处理HepG2细胞，采用MTT法检测HepG2细胞增殖情况，流式......
Globally,the risk of colorectal cancer（CRC） as well as the incidence of mortality associated with CRC is increasing.Thus,i......
目的研究水飞蓟宾磷脂酰胆碱复合物（SPC）与水飞蓟宾对四氯化碳所致小鼠肝损伤的保护作用。方法选择100只健康成年的昆明小鼠,按照随......
由于肿瘤的异质性,抗肿瘤药物作用不同的肿瘤模型时表现出不同的敏感性和不同的作用机制.将水飞蓟宾分别作用乳腺癌细胞MCF-7和卵......
目的：探讨水飞蓟宾对抗结核药物引起的肝功能损害患者进行预防性治疗后的肝脏的保护作用。方法：随机将病人两组，治疗组30例，对照组24例......
目的研究水飞蓟宾(Silibinin,Slybin)在体外对人肝癌细胞株HepG2的抗增殖作用及其机制.方法 MTT法观察水飞蓟宾对细胞增殖的抑制作......
研究壳脂胶囊与水飞蓟宾联合治疗非酒精性脂肪肝病患者的疗效。方法 选取本院2015年1月至2017年6月非酒精性脂肪肝病患者137例，依据......
