FLUOROQUINOLONE相关论文
Multiple genes encoding fluoroquinolone resistance co-located with ESBL genes in non-typhoidal salmo
OBJECTIVES To investigate the molecular epidemiology of genes that confer resistance to fluoroquinolones and extended sp......
Fluoroquinolones(FQs)are a widely used class of synthetic antibiotics with broad activity spectrum of mycoplasma and bac......
Influence of planting patterns on fluoroquinolone residues in the soil of an intensive vegetable cul
Recent studies have demonstrated the persistence of antibiotics in soil,especially in areas of vegetable culti-vation.Ho......
Accumulation of ciprofloxacin and lomefloxacinin fluoroquinolone- resistant strains of Escherichia c
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为寻找由氟喹诺酮抗菌活性到抗肿瘤活性转化的有效途径,用均三唑和(口恶)二唑分别作为培氟沙星C-3羧基的等排体和修饰基,设计合成......
Cloning and Sequence Analysis of gyrB Gene of Fluoroquinolones-resistant Salmonella Isolated from Ch
Nine strains resistant to five fluoroquinolones (Ciprofloxacin, Ofloxacin, Enrofloxacin, Danofloxacin,Sarafloxacin) were......
目的比较铜绿假单胞菌(PA)经不同浓度环丙沙星(CIP)、左氧氟沙星(LEV)和诺氟沙星(NOR)体外共培养后耐药性的变化，从中优选治疗PA感......
Fluoroquinolone Resistance and Mutation Patterns in gyrA and parC Genes in Neisseria gonorrhoeae Iso
In order to study the resistance of Neisseria (N.) gonorrhoeae to the fluoroquinolone and detect mutation patts of quino......
Spectroscopic Investigations for the Six New Synthesized Complexes of Fluoroquinolones and Quinolone
Quinolone has a broad spectrum of synthetic antibiotics with a strong therapeutic effect and quinolone is a term used fo......
Spectroscopic Investigations for the Six New SynthesizedComplexes of Fluoroquinolones and Quinolones
Quinolone has a broad spectrum of synthetic antibiotics with a strong therapeutic effect and quinolone is a term used fo......
目的分析氟喹诺酮类与茶碱类联用致不良事件的特点,为临床合理用药提供参考。方法检索Pub Med、CNKI、VIP、CMB和万方数据有关氟喹......
目的 研究化脓性胆管炎患者胆汁培养粪肠球菌基因序列,分析其对6种氟喹诺酮类药物的耐药性. 方法 对2009～2013年齐齐哈尔医学院附属......
Accumulation of ciprofloxacin and lomefloxacinin fluoroquinolone-resistant strains of Escherichia co
Objective To evaluate the role of outer membrane protein (Omp) F-deficiency and active efflux in the accumulation of hyd......
,Piperonal ciprofloxacin hydrazone induces growth arrest and apoptosis of human hepatocarcinoma SMMC
...
Development and validation of a simple UV spectrophotometric method for the determination of levoflo
A rapid, specific and economic UV spectrophotometric method has been developed using a solvent composed of water:methano......
Design, Synthesis and Antitumor Activity of Fluoroquinolone C3 Heterocyclic Bis-oxadiazole Methylsul
本文通过对荣华二采区10...
Synthesis and in vitro antibacterial activities of 7-(3-aminopyrrolo[3,4-c]pyrazol-5(2H,4H,6H)-yl)qu
为探究吕家坨井田地质构造格局,根据钻孔勘探资料,采用分形理论和趋势面分析方法,研究了井田7......
Synthesis and antitumor evaluation of C3/C3 fluoroquinolone dimers (I): Tethered with a fused hetero
为探究吕家坨井田地质构造格局,根据钻孔勘探资料,采用分形理论和趋势面分析方法,研究了井田7......
Synthesis and in vitro antibacterial activities of 7-(4-alkoxyimino-3-hydroxypiperidin- l-yl)quinolo
为探究吕家坨井田地质构造格局,根据钻孔勘探资料,采用分形理论和趋势面分析方法,研究了井田7......
Synthesis and antitumor evaluation of fluoroquinolone C3 fused heterocycles (Ⅱ): From triazolothiadi
为探究吕家坨井田地质构造格局,根据钻孔勘探资料,采用分形理论和趋势面分析方法,研究了井田7......
Synthesis and antitumor and antibacterial evaluation of fluoroquinolone derivatives (Ⅲ) : Mono-and b
为探究吕家坨井田地质构造格局,根据钻孔勘探资料,采用分形理论和趋势面分析方法,研究了井田7......
基于抗菌氟喹诺酮作用靶拓扑异构酶设计发展新型抗肿瘤氟喹诺酮药物已成为新的研究方向.为扩展氟喹诺酮C-3稠杂环体系的研究领域,......
Accumulation of ciprofloxacin and lomefloxacinin fluoroquinolone-resistant strains of Escherichia co
Objective To evaluate the role of outer membrane protein (Omp) F-deficiency and active efflux in the accumulation of hyd......
Synthesis and in vitro antibacterial activities of 7-(4-alkoxyimino-3-hydroxypiperidin- l-yl)quinolo
A series of novel 7-(4-alkoxyimino-3-hydroxypiperidin-l-yl)quinolone derivatives were designed, synthesized and evaluate......
Synthesis and in vitro antibacterial activities of 7-(3-aminopyrrolo[3,4-c]pyrazol-5(2H,4H,6H)-yl)qu
A series of novel 7-(3-aminopyrrolo[3,4-c]pyrazol-5(2H,4H,6H)-yl)quinolone derivatives were designed, synthesized and ev......
Cloning and Sequence Analysis of gyrB Gene of Fluoroquinolones-resistant Salmonella Isolated from Ch
Nine strains resistant to five fluoroquinolones (Ciprofloxacin, Ofloxacin, Enrofloxacin, Danofloxacin,Sarafloxacin) were......
为寻找抗肿瘤氟喹诺酮C-3羧酸等排体的有效优化策略,基于C-3均三唑-(口恶)二唑甲硫醚(6a～6j)结构特征,在培氟沙星(1)羧基等排体均三......
建立了生鲜牛乳中8种氟喹诺酮类药物的超高效液相色谱串联质谱的测定方法。生鲜牛乳经QuEChERS萃取剂提取,QuEChERS净化剂净化后,......
Synthesis and antitumor evaluation of C3/C3 fluoroquinolone dimers (I): Tethered with a fused hetero
Five C3/C3 fluoroquinolone dimers tethered with a fused heterocyclic ring of s-triazolo[2,1-b][1,3,4]thiadiazole derived......
Synthesis and antitumor evaluation of fluoroquinolone C3 fused heterocycles (Ⅱ): From triazolothiadi
To further expand an effective modified route for the shift from an antibacterial fluoroquinolone (FQ) to an antitumor F......
目的 比较和探讨3种氟喹诺酮类药物(氧氟沙星、左氧氟沙星、莫西沙星)治疗耐药肺结核(MDR-TB)的经济效果和最佳治疗方案.方法 将经......
Synthesis and antitumor and antibacterial evaluation of fluoroquinolone derivatives (Ⅲ) : Mono-and b
To further explore an efficient modified route for the shift from an antibacterial fluoroquinolone to an antitumor one,m......
为寻找提高氟喹诺酮肿瘤活的有效结构修饰策略,左氧氟沙星(3)的衍生物(S)-(-)-9-氟-2,3-二氢-3-甲基-10-(4-甲基-1-哌嗪基)-[1,4]......
为发现氟喹诺酮由抗菌活性向抗肿瘤活性转化的结构修饰方法,基于生物电子等排药物设计原理,用唑杂环作为氧氟沙星(1)C-3羧基的等排......
以液相色谱-质谱/质谱法为基础,在试验前处理方面进行了优化,通过添加回收试验和阳性样品检测,对比液相色谱-质谱/质谱法和优化后......
为了探讨金黄色葡萄球菌的氟喹诺酮耐药性与grlA、grlB基因突变的关系,从52株野生型金黄色葡萄球菌中筛选出1株对氟喹诺酮敏感的金......
摘要基于抗菌氟喹诺酮的作用靶拓扑异构酶与哺乳动物的相似性，为寻找由抗菌活性到抗肿瘤活性转化的有效修饰方法，用嘿二唑杂环作为诺......
用噁二唑硫酮杂环作为培氟沙星（1）的C3羧基电子等排体,得中间体C3噁二唑硫酮4（5）,再将其与仲胺或取代苯胺及甲醛通过氨甲基化反应形成......
为进一步发展抗菌药氟喹诺酮向抗肿瘤活性转化的有效结构修饰策略,基于药效团骨架的迁越药物设计原理,用噻唑并均三唑稠环取代左氧......
取临床分离的、对5种氟喹诺酮类药物（环丙沙星、氧氟沙星、恩诺沙星、单诺沙星和沙拉沙星）均耐药的9株鸡源性沙门氏菌耐药株,提取其......
为研究盐酸恩诺沙星、乳酸恩诺沙星和乳酸诺氟沙星对嗜水气单胞菌（Aeromonas hydrophila）、鳗弧菌（Vibrio anguillarum）和哈维氏弧菌（Vi......
Helicobacter pylori(H. pylori) is a widespread pathogen infecting about 40% of people living in urban areas and over 90%......
５，７，８位取代的喹诺酮类化合物定量构效关系的量子化学研究俞庆森，朱龙观，林瑞森，蔡国强（浙江大学化学系杭州３１００２７）关键词：氟喹喏酮类，定量构效关系，ＣＮＤＯ／２氟......
目的寻找新型的嗯唑烷酮-氟喹诺酮类抗菌药物。方法设计合成了7-{4-[2-[2-取代4-（（5S）-5-乙酰胺甲基-2-氧代-噁唑烷-3-基）苯基]乙基]哌......
〔目的〕寻找氟喹诺酮C-3羧基的有效生物等排体。〔方法〕用均三唑并噻二唑稠杂环作为环丙沙星C-3羧基的生物电子等排体，合成了10个......
采用过碘酸钠法将抗环丙沙星单克隆抗体（MAb-CIP）与辣根过氧化物酶（HRP）偶联制备酶标抗体MAbCIP-HRP,建立了检测水产品中6种氟喹诺酮类......
目的:了解 2000年～ 2002年氟喹诺酮类药物在西南 4省市医院中的应用情况,评估其现状和趋势.方法:对西南 4省市 51家医院应用氟喹诺......
分离鉴定临床表葡菌126株,通过Kirby-Bauer法和平皿二倍稀释法测定了126株临床分离表皮葡萄球菌对13种抗菌药物(甲氧西林、卡那霉......
