Celastrol相关论文
越来越多的研究表明,雷公藤红素可以诱导细胞凋亡,但是其对食管癌细胞的作用尚未可知.该研究通过体外实验探讨了雷公藤红素对食管......
Objective:Toinvestigatetheeffectofcelastrolonviabilityandapoptosisofosteosarcomacellsandfurthermore,toilluminatethe mole......
Celastrol inhibit malignant phenotype of human osteosarcoma cells via the mitochondrial apoptotic pa
Objective The present study was undertaken to determine the effect of celastrol on malignant phenotype of human osteosar......
Celastrolnegativelyregulatescellinvasionandmigrationabilityofhumanosteosarcomaviadownreg
Objective:ToinvestigatetheeffectsofcelastrolonthemigrationandinvasionofhumanosteosarcomaU-2OScellsinvitro.......
Targeting Mast Cells and Basophils with Anti-FcεRIα Fab-Conjugated Celastrol-Loaded Micelles Suppres
Mast cells and basophils are effector cells in the pathophysiology of allergic diseases.Targeted elimination of these ce......
Protective effect of celastrol in rat cerebral ischemia model:Down-regulating p-JNK,p-c-Jun and NF-κ
Background:Oxidative stress and inflammatory damage play an important role in cerebral ischemic pathogenesis and may rep......
Synergistic Anticancer Effects of Triptolide and Celastrol, Two Main Compounds from Thunder God Vine
Objective Triptolide and celastrol are two most widely studied and promising compounds isolated from Thunder God Vine (T......
Celastrol prevents cadmium-induced neuronal cell death by blocking mitochondrial ROS inactivation of
We have recently reported that celastrol prevents cadmium(Cd)-induced neuronal cell death by inhibiting Cd-activation of......
Oxidative stress by cadmium(Cd)intoxication has been accepted as a possible etiological factor of neurodegenerative dise......
Celastrol,is an active compound extracted from the root bark of the traditional Chinese medicine Tripterygium wilfordii ......
Effects of celastrol, derived from Trypterygium wilfordii Hook F, on metabolism of model Cyp1A2, 2C1
Aim: The present study was to investigate the effects of celastrol, derived from Trypterygium wilfordii Hook F ("Thunde......
Celastrol, a bioaetive compound extracted from Tripterygium wilfordii Hook F., has recently attracted much attention for......
Antioxidant Effects of Celastrol Against Hydrogen Peroxide-Induced Oxidative Stress in The Cell Mode
Amyotrophic lateral sclerosis(ALS)is a common adult onset motor neuron(MN)disease leading to rapidly progressive degener......
Celastrol inhibits interleukin-17A-stimulated rheumatoid fibroblast-like synoviocyte migration and i
...
Increase of reactive oxygen species-mediated apoptosis by celastrol in taxol-sensitive and-resistant
Objective: Taxol resistance is a major challenge in non-small cell lung cancer(NSCLC)treatment.In this study,the anti-ca......
Celastrol,a pentacyclic triterpene extracted from traditional Chinese medicial plant tripterygium wilfordii,presents obv......
Celastrol inhibits interleukin-17A-stimulated rheumatoid fibroblast-like synoviocyte migration and i
Interleukin-17A (IL-17A)-induced migration and invasion of fibroblast-like synoviocytes (FLSs) is critical for the patho......
Celastrol induces apoptosis in human hepatocellular carcinoma Bel-7402 cells through both mitochondr
...
雷公藤红素(CSL)是一种醌甲基三萜类成分，具有多种药理活性，其 中以抗癌、抗炎活性最为显著，但其毒性也不容忽视。口服后易产生全身性......
Celastrol is a triterpene derived from the traditional Chinese medicine Tripterygium wilfordii Hook f,which displays pot......
An integrated quantitative proteomics strategy reveals the dual mechanisms of celastrol against acut
Inflammation is a defense mechanism associated with a wide range of diseases. Celastrol is a small molecule isolated fro......
Metabolic syndrome is a clustering of metabolic disorder with unclear molecular mechanism.Increasing studies have found ......
Celastrol suppressesthe proliferation of lung adenocarcinoma cells through regulating miR-24 and miR
Cumulative evidence indicated that celastrol could suppress cancer growth,but the mechanism of which needs to be fur......
Celastrol is a pentacyclic triterpenoid isolated from Tripterygium wilfordii that has long been used in traditional Chin......
...
The endothelial-to-mesenchymal transition (EndMT) in endothelial cells contributes to the development of cardiac fibrosi......
Celastrol induces caspase-dependent apoptosis of hepatocellular carcinoma cells by suppression of ma
OBJECTIVE: To investigate the efficacy of celastrol treatment of hepatocellular carcinoma(HCC) cells in vitro and in viv......
Celastrol,a Chinese herbal medicine,has exhibited anticancer activity in many types of cancer cells.However,the further ......
目的研究南蛇藤根皮中化学成分。方法采用反复硅胶柱色谱及Sephadex LH-20柱色谱进行分离纯化,根据理化常数和光谱数据进行结构鉴......
In vitro 3D phenotypic drug screen identifies celastrol as an effective in vivo inhibitor of polycys
Polycystic kidney disease (PKD) is a prevalent genetic disorder, characterized by the formation of kidney cysts that pro......
研究了从独子藤中提取雷公藤红素的关键提取参数,包括提取时间(10-20 min),提取温度(30-60℃),超声功率(60-90 W)和液料比(10-30 m......
Due to the critical correlation between inflammation and carcinogenesis,a therapeutic candidate with anti-inflammatory a......
...
[目的]研究雷公藤红素对3T3细胞的毒性作用,获得的细胞毒性结果预测急性毒性半数致死量(LD50),并与采用小鼠上下法(UDP)和Bliss法......
目的 研究雷公藤红素体外对人类急性髓系白血病(AML)细胞的体外抑制作用.方法 应用四甲基偶氮唑蓝(MTT)法和流式细胞术(FCM)等方法......
目的探讨雷公藤红素(celastrol)联合tPA治疗急性脑缺血再灌注损伤的作用及机制。方法大鼠随机分为假手术组和造模组,造模组建立大......
目的 探讨雷公藤红素对体外C6胶质瘤细胞凋亡及细胞周期阻滞的影响及机制.方法 雷公藤红素处理体外培养的C6胶质瘤细胞,MTT法检测......
...
雷公藤红素是源于雷公藤根部的重要活性成分,在促进脂质消耗、控制体质量等方面拥有独特效果,被公认为是最有潜力的减肥活性成分。......
目的观察预知子醇提物联合雷公藤红素对SMMC7721细胞增殖和凋亡的影响,探讨其可能的作用机制。方法将不同浓度预知子醇提物和雷公......
目的 探究雷公藤红素对人子宫内膜癌HHUA细胞增殖、周期及凋亡的影响.方法 采用MTT法分析雷公藤红素对HHUA细胞增殖的影响,流式细......
雷公藤红素(Celastrol)是传统中药雷公藤(Tripterygium wilfordii)的根部提取的五环三萜类化合物,近年来大量实验研究证明具有抗炎......
雷公藤红素（Celastrol）ip1,3mg/kg×5d能明显减轻小鼠胸腺的重量,降低小鼠脾脏空斑形成细胞数,同时提高血清补体C<sub>3</sub>含......
目的评价姜黄素联合雷公藤红素体内外抗胃癌作用及联用优势。方法CCK-8法和流式细胞仪法检测姜黄素、雷公藤红素、姜黄素+雷公藤红......
目的：研究雷公藤红素对人前列腺癌（PCa）细胞生长、凋亡及SUMO特异蛋白酶1（SUMO-specificproteases 1,SENP1）基因表达的影响。方法：对前列......
目的观察雷公藤红素对前脂肪细胞3T3-L1成脂分化的影响,并探讨其作用机制。方法用脂肪细胞诱导培养基培养3T3-L1细胞,分别给予0、0......
目的：探讨雷公藤红素对人肝癌MHCC97H细胞侵袭转移的抑制作用及相关机制。方法：应用Transwell技术观察不同浓度（2.5μmol·L^-1、......
以离体小鼠皮肤为屏障,采用TP2A型智能透皮试验仪进行体外透皮试验,用HPLC法测定不同促渗剂对雷公藤红素醇质体的累积渗透量和渗透......
南蛇藤素（Ｃｅｌ）对豚鼠精子前向运动（ＦＭ），获能（Ｃａｐ），顶体反应（ＡＲ）和穿透去透明仓鼠卵（ＳＰＡ）均有明显的抑制作用，其作用强度随剂量而增加，对Ｃｅｌ的敏感性依次为精子Ｃａｐ〉ＦＭ〉......
