论文部分内容阅读
为探讨血管紧张素Ⅰ转化酶(ACE)基因插入/缺失(Ⅰ/D)多态性与儿童原发性肾病综合征(PNS)的相关性。我们选取PNS组患儿103例,其中激素敏感组54例,激素耐药组49例,正常组为健康儿童114例,采用聚合酶链反应技术(PCR)分析ACE基因Ⅰ/D多态性与在各组中的分布,并进行统计学分析。结果显示PNS组与正常组ACEⅠ/D基因型及等位基因频率分布比较差异无统计学意义,激素敏感组与激素耐药组ACEⅠ/D基因型及等位基因频率分布比较差异也无统计学意义。本研究表明ACEⅠ/D基因多态性与PNS的发生无明确关联;ACEⅠ/D基因多态性与激素治疗效应也无明确关联。
To investigate the association of angiotensin I converting enzyme (ACE) gene insertion / deletion (Ⅰ / D) polymorphisms with childhood nephrotic syndrome (PNS). We selected 103 PNS patients, including hormone-sensitive group of 54 cases, hormone-resistant group of 49 cases, normal group of 114 healthy children, using polymerase chain reaction (PCR) analysis of ACE gene I / D polymorphism and Distribution in each group, and statistical analysis. The results showed that there was no significant difference in ACEⅠ / D genotype and allele frequency distribution between PNS group and normal group. There was also no significant difference in ACEⅠ / D genotype and allele frequency between hormone sensitive group and hormone resistant group significance. This study showed that ACE Ⅰ / D gene polymorphism and PNS no clear correlation; ACE Ⅰ / D gene polymorphism and hormone therapy effect is not clear correlation.