氯胺酮(Ketamine,KT)是常用的静脉全麻药,但有躁动、血压和肌张力增高、精神症状等不良反应。可乐定(Clonidine,CL)是中枢性降压药,为α_2-受体激动剂,近年来发现有镇痛、镇静等作用,可增强氟烷、异氟醚、异丙酚、芬太尼和舒芬太尼的作用,但极少有CL与KT相互作用的报道。本文用动物实验观察了二药镇 Ketamine (Ketamine, KT) is a commonly used intravenous anesthetics, but there are agitation, blood pressure and muscle tone increased, mental symptoms and other adverse reactions. Clonidine (CL) is a central antihypertensive drug, α 2 -receptor agonist, in recent years found analgesic, sedative and other effects, can enhance the halothane, isoflurane, isoflurane, propofol, fentanyl and Sufentanil, but few reports of the interaction between CL and KT. In this paper, animal experiments observed two drug town