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小白鼠置于标准光－暗条件中饲养２ｗｋ后，采用热板法，在昼夜６个时间点测痛阈值，结果呈现明显的昼夜节律，峰、谷时间在２４：００和１２：００时分别为（２７．８土３．０）ｓ和（１９．６土２．８）ｓ．热辐射刺激鼠尾痛阈也存在昼夜节律，峰、谷时间仍在２４：００和１２：００时，痛阈分别是（１８．３±３．０）ｓ和（１０．９±０．８）ｓ．扭体实验亦证明有昼夜节律．用切除松果体（Ｐｉｎｅａｌｅｃｔｏｍｙ，Ｐｘ）的小鼠重复上述实验，痛阈值减小，痛觉敏感性增强，而且昼夜节律消失，对动物进行持续光照或黑暗２ｗｋ，均明显改变其痛觉敏感性．结果表明：痛觉敏感性有昼夜节律．Ｐｘ使痛觉昼夜节律消失．说明松果体参予痛觉过程，而且与痛觉昼夜节律的形成有关．
The mice were placed in standard light - dark conditions raised 2wk, the hot plate method, the six points in the day and night pain threshold, the results showed significant circadian rhythm, peak, valley time at 24:00 and 12:00 respectively (27.8 earth 3.0) s and (19.6 earth 2.8) s. Thermal radiation stimulated murine tail pain threshold also exists circadian rhythm, peak and valley time is still 24:00 and 12:00, the pain threshold were (18.3 ± 3.0) s and (10.9 ± 0.8 ) S. Twisting experiments also proved to have circadian rhythms. Repeated the above experiments with mice excised pinealctomy (Px), pain threshold decreased, hyperalgesia increased, and circadian rhythms disappeared, the animals continued to light or dark 2wk, were significantly changed the pain sensitivity. The results showed that: analgesia has circadian rhythm. Px pain disappeared circadian rhythm. Pineal gland involvement in pain process, but also with the formation of pain circadian rhythm.