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目的研究姜黄素及其衍生物体内抗炎活性。方法通过建立二甲苯致小鼠耳廓肿胀和角叉菜胶致小鼠足肿胀炎症模型,探讨姜黄素及其衍生物体内抗炎作用;观察姜黄素及其衍生物对前列腺素E2,总抗氧化能力,丙二醛的影响。结果与模型组相比,姜黄素及其衍生物对二甲苯致小鼠耳廓肿胀和角叉菜胶致小鼠足肿胀有不同程度的改善(P<0.05,P<0.01);与模型组相比,姜黄素及其衍生物不同程度的降低血浆中丙二醛含量、升高总抗氧化能力含量和降低炎症组织中前列腺素E2的含量(P<0.05,P<0.01)。结论姜黄素及其衍生物皆有抗炎的活性,其抗炎活性可能与其提高小鼠体内抗氧化能力和抑制炎症组织内前列腺素E2的合成有关。
Objective To study the anti-inflammatory activity of curcumin and its derivatives in vivo. Methods The model of mouse foot swollen inflammation caused by xylene-induced ear auricle swelling and carrageenan in mice was established to investigate the anti-inflammatory effect of curcumin and its derivatives in vivo. The effects of curcumin and its derivatives on the expression of prostaglandin E2 Oxidation capacity, effects of malondialdehyde. Results Compared with the model group, curcumin and its derivatives improved the auricle swelling induced by xylene and the carrageenan-induced foot swelling in mice to some extent (P <0.05, P <0.01). Compared with the model group In contrast, curcumin and its derivatives decreased plasma MDA, increased total antioxidant capacity and decreased the level of prostaglandin E2 in inflammatory tissues (P <0.05, P <0.01). Conclusion Curcumin and its derivatives all have anti-inflammatory activity, and its anti-inflammatory activity may be related to its ability to increase antioxidant capacity and inhibit the synthesis of prostaglandin E2 in inflammatory tissues.