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肥胖症是威胁现代人健康的重要疾病,它增加了糖尿病、高血压、高脂血症等疾病的发病率。肥胖的根本原因是机体能量摄入和消耗的失衡。食欲肽(orexin)是由下丘脑特异性分泌的一种能调节睡眠、摄食及能量平衡的神经肽。新近的研究表明,增加食欲肽水平和/或食欲肽的敏感性可通过提高机体自发活动(spontaneous physical activity,SPA)诱导的非运动生热作用(nonexercise activity thermogenesis,NEAT)而实现肥胖抵抗,进而开辟了一条治疗肥胖的新途径。该文综述了受食欲肽调控的SPA和NEAT与肥胖抵抗的关系,分析了食欲肽受体信号通路与肥胖的相关性,并阐释了食欲肽作为预防和治疗肥胖的分子靶标的作用机理。
Obesity is an important disease threatening the health of modern people. It increases the incidence of diseases such as diabetes, hypertension and hyperlipidemia. The underlying cause of obesity is the imbalance of energy intake and consumption. Orexin is a neuropeptide that is specifically secreted by the hypothalamus and regulates sleep, feeding and energy balance. Recent studies have shown that increasing orexin levels and / or orexin sensitivity can achieve obesity resistance by increasing spontaneous physical activity (SPA) -induced non-exercise thermogenesis (NEAT) Opened up a new way to treat obesity. This review summarizes the relationship between orexin-regulated SPA and NEAT and obesity resistance, correlates the orexin signaling pathway with obesity, and elucidates the mechanism of orexin as a molecular target for the prevention and treatment of obesity.