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目的探讨中枢神经系统炎症患者脑脊液一氧化氮含量及其意义。方法采用荧光分光光度法对３９例中枢神经系统炎症患者和１８例对照组脑脊液（ＣＳＦ）中的一氧化氮（ＮＯ）含量进行检测，并同时进行细胞学检查。结果中枢神经系统炎症患者ＣＳＦ中ＮＯ含量显著高于对照组（Ｐ＜０．０５），细菌性脑膜炎（菌脑）患者（１３例）虽高于单纯疱疹病毒性脑炎（ＨＳＥ）患者（２６例），但无统计学差异（Ｐ＞０．０５）。菌脑ＣＳＦ白细胞计数和炎性嗜中性粒细胞比例均明显增高；ＨＳＥＣＳＦ细胞学检查则以淋巴细胞反应为主，白细胞计数轻度增高。结论在中枢神经系统炎症患者的病理过程中确有过量的ＮＯ存在和参与，且与ＣＳＦ中炎性嗜中性粒细胞和激活淋巴细胞的增多具有同步性；不同致病源ＮＯ含量的升高也不同。
Objective To investigate the content of nitric oxide in cerebrospinal fluid in patients with central nervous system inflammation and its significance. Methods The contents of nitric oxide (NO) in cerebrospinal fluid (CSF) of 39 patients with central nervous system inflammation and 18 controls were detected by fluorescence spectrophotometry. Cytological examination was performed at the same time. Results The concentration of NO in the CSF of patients with central nervous system inflammation was significantly higher than that of the control group (P <0.05). The patients with bacterial meningitis (13 cases) were higher than those with HSV 26 cases), but no statistical difference (P> 0.05). CSF CSF white blood cell count and inflammatory neutrophil ratio were significantly increased; HSECSF cytology is the main lymphocyte reaction, mildly elevated white blood cell count. Conclusions There is indeed an excessive presence and involvement of NO in the pathological process of patients with central nervous system inflammation, and it is in synchronicity with the increase of inflammatory neutrophils and activated lymphocytes in CSF. The content of NO in different pathogens is increased Also different.