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AIM: To investigate whether the aquaporin-1 (AQR-1) geneexpression can be regulated by acetazolamide, a carboincanhydrase inhibitor in rat kidney. Carbonic anhydrase inhibitor isone of the diuretics with the site of action on renal proximaltubules. And AQP-1 wate channel is located on the epithelialcells of the renal proximal tubules with the function of facilitatingwater transport across proximal tubules epithelia. METHODS:The kidneys were excised from immature (20 d) female rat at
AIM: To investigate whether the aquaporin-1 (AQR-1) geneexpression can be regulated by acetazolamide, a carboincanhydrase inhibitor in rat kidney. And AQP-1 wate channel is located on the epithelial cells of the renal proximal tubules with the function of facilitating water transport proximal proximal tubule epithelia. METHODS: The kidneys were excised from immature (20 d) female rat at