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在合成2-氯烟酸的工艺路线中,最关键的一个环节就是烟酰胺-N-氧化物的氯化反应过程,该过程直接影响2 -氯烟酸产品的收率和质量。我们通过大量的实验及对实验数据进行分析,发现该反应过程是一个需要严格控制反应条件的过程,尤其对温度要严格控制。反应过程中添加的三氯氧磷的量也要严格控制。介绍了最佳工艺条件,为2-氯烟酸的合成提供了最佳的小试数据,为进一步开展扩试工作,提供了可靠的依据。
The key step in the synthesis of 2-chloronicotinic acid is the chlorination of nicotinamide-N-oxide, which directly affects the yield and quality of the 2-chloronicotinic acid product. We through a large number of experiments and analysis of experimental data and found that the reaction process is a need to strictly control the reaction conditions, especially for the temperature to be strictly controlled. The amount of phosphorus oxychloride added during the reaction should be controlled as well. The best process conditions were introduced, which provided the best experimental data for the synthesis of 2-chloronicotinic acid, which provided a reliable basis for further expansion test.