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本文报道硫酸镁对洋地黄治疗并发室性心律失常的作用。28例各种原因的心脏病患者,临床上有心力衰竭的表现,X线检查心脏增大。所有患者口服洋地黄10天,均有室性心律失常(其中除3例为偶发室性期外收缩外,其余为室性早搏呈联律、多源室性早搏或室性心动过速)。以缓慢静脉滴注硫酸镁(30～50毫克/分)控制心律失常。然后静脉注射毒毛旋花子甙K,1/16～1/8毫克,每日2次,每次用药前以同样速度静脉滴注硫酸镁60分钟,并在其前后分别测定血清镁变化。结果:静脉滴注硫酸镁使心室兴奋性异常消失,1例完全性房室传导阻滞伴室性早搏患者,经用硫酸镁后,室性早搏消失,但逸搏心律无改变。这些疗效多见于用药20～40分钟后。静脉滴注60分钟后血清镁浓度(1.98±0.23毫当量/升)与基础时(1.67±0.26毫当量/升)无明显差别。在镁离子的保护下,每天应用二次毒毛旋花子甙K,不仅使心力衰竭临床表现好转,而且心脏缩小。
This article reports the effect of magnesium sulfate on digitalis in the treatment of ventricular arrhythmias. 28 patients with various causes of heart disease, clinical manifestations of heart failure, X-ray examination of the heart increased. All patients were given digitalis for 10 days. All of them had ventricular arrhythmia. Among them, 3 cases were occasional ventricular contraction, the others were ventricular premature beats, multi-source ventricular premature beats or ventricular tachycardia. Slow intravenous infusion of magnesium sulfate (30 ~ 50 mg / min) to control arrhythmia. Then intravenous injection of poisoned spinoside K, 1/16 ~ 1/8 mg twice daily before the medication at the same speed intravenous infusion of magnesium sulfate for 60 minutes, before and after the determination of changes in serum magnesium. Results: Intravenous magnesium sulphate ablated the ventricular excitability abnormality. One case of complete atrioventricular block with premature ventricular contractions, ventricular premature beat disappeared after using magnesium sulphate, but the escape rhythm did not change. These effects more common in medication 20 to 40 minutes later. Serum magnesium concentration (1.98 ± 0.23 meq / L) after 60 minutes of IV infusion did not differ significantly from baseline (1.67 ± 0.26 meq / L). Under the protection of magnesium ions, twice daily application of venom aglycon K, not only to improve the clinical manifestations of heart failure, and reduce the heart.