论文部分内容阅读
目的观察不同类型心绞痛患者支架术前后血浆 C-反应蛋白浓度的变化及其意义。方法选择15例冠心病进行支架术的患者(稳定性心绞痛组13例;不稳定性心绞痛组38例)作为研究对象,同时选择一组同期进行冠脉造影的患者为对照组。分别于支架术或造影术前当天早晨、术后48h 采集静脉血进行血浆 C-反应蛋白。结果术前,稳定性心绞痛组与冠脉造影组比较,C-反应蛋白水平无显著差异;不稳定性心绞痛组 Braunwald Ⅱ、Ⅲ级与稳定性心绞痛组、冠脉造影组比较 C-反应蛋白水平均有显著性升高,P 值均小于0.05。但不稳定性心绞痛各亚组间 C-反应蛋白差异无显著性。术后,冠脉造影组 C-反应蛋白浓度与造影前比较无显著差异(P>0.05)。但观察组稳定性心绞痛组、不稳定性心绞痛各亚组术后 C-反应蛋白均显著升高,且随不稳定性心绞痛临床分级增加升高越显著,各组间比较差异均有显著性意义。复杂病变型与简单病变型比较术后 C-反应蛋白升高有显著意义(P<0.01)。观察组术后 C-反应蛋白浓度与术前无显著直线相关(r=0.32,P>0.05)。结论冠状动脉支架术增加不同类型心绞痛患者血浆 C-反应蛋白水平;不稳定性心绞痛临床分级越重,术后 C-反应蛋白水平升高越明显,提示 C-反应蛋白水平可作为冠状动脉病变不稳定性的预测指标。
Objective To observe the changes of plasma C-reactive protein level before and after stent implantation in patients with different types of angina pectoris and its significance. Methods Fifteen patients with coronary heart disease undergoing stenting (13 cases of stable angina pectoris group and 38 cases of unstable angina pectoris group) were selected as the study subjects. A group of patients undergoing coronary angiography at the same time were selected as the control group. Venous blood was collected for plasma C-reactive protein at 48 h after surgery, respectively, on the day before stenting or preoperative angiography. Results Before operation, there was no significant difference in C-reactive protein between stable angina group and coronary angiography group. Compared with coronary angiography group, the level of C-reactive protein in patients with unstable angina pectoris was significantly higher than that of stable angina pectoris group Significantly increased, P values were less than 0.05. However, there was no significant difference in C-reactive protein between the subgroups of unstable angina. Postoperatively, C-reactive protein concentrations in coronary angiography did not differ significantly from those before angiography (P> 0.05). However, the postoperative C-reactive protein in the stable angina group and the unstable angina pectoris group in the observation group were significantly increased, and the clinical classification with unstable angina pectoris increased more significantly, the differences between the groups were significant . Complicated lesions and simple lesions compared with postoperative C-reactive protein increased significantly (P <0.01). The postoperative C-reactive protein concentration in the observation group had no significant linear correlation with preoperative (r = 0.32, P> 0.05). Conclusion Coronary artery stenting increases the plasma C-reactive protein level in patients with different types of angina pectoris. The more severe clinical grades of unstable angina pectoris are, the more obvious the elevated C-reactive protein level after surgery, suggesting that C-reactive protein level can be used as coronary artery lesion Predictors of stability.