α-黑素细胞刺激素对神经系统损伤具有明显保护作用,可抑制神经损伤后炎症反应及促进神经损伤后轴突再生和功能恢复。主要是通过作用于黑皮质素受体,抑制核转录因子(NF-κB)激活、减轻炎性细胞因子过度释放、增加神经细胞内腺苷酸环化酶含量等机制发挥作用。 α-melanocyte stimulating hormone has a significant protective effect on nervous system injury, which can inhibit inflammatory reaction after nerve injury and promote axonal regeneration and functional recovery after nerve injury. Mainly through acting on melanocortin receptors, inhibiting the activation of nuclear transcription factor (NF-κB), reducing the excessive release of inflammatory cytokines and increasing the content of adenylate cyclase in nerve cells and other mechanisms.