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目的探讨宫腔细胞学检查在子宫内膜癌筛查的诊断价值。方法计算机检索1970~2014年国内外公开发布的以子宫内膜病理检查为金标准的关于宫腔细胞学筛查的中英文文献,提取相关数据。根据Cochrane协作网推荐的方法对文献进行质量评价,并用Stata 12.0软件进行统计分析。结果共纳入文献15篇,子宫内膜癌细胞学筛查的合并敏感度和特异度分别为0.86、1.00,诊断比值比为1 241.00,合并阳性和阴性似然比分别为175、0.14,总受试者工作特征曲线下面积为0.99。结论宫腔细胞学检查用于筛查子宫内膜癌具有可行性。
Objective To investigate the diagnostic value of uterine cytology in the screening of endometrial cancer. Methods Chinese and English literatures about uterine cytology screening with endometrial histopathology as the gold standard published from 1970 to 2014 were searched by computer and the related data were extracted. The quality of the literature was evaluated according to the recommendations of the Cochrane Collaboration, and statistical analysis was performed using Stata 12.0 software. Results A total of 15 articles were included in the literature. The combined sensitivity and specificity of cytological screening for endometrial cancer were 0.86 and 1.00, respectively, and the diagnostic odds ratio was 1 241.00. The positive and negative likelihood ratios for combined screening were 175 and 0.14 respectively. The area under the trial work characteristic curve was 0.99. Conclusion Intrauterine cytology is a feasible method for screening endometrial cancer.