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缺氧诱导因子 (HIF 1)是调节缺氧反应基因的一个核转录因子 ,现认为它在肿瘤 ,尤其是乏氧肿瘤(如肺癌 )的发病及疾病的发展过程中起着重要的作用。本文拟就这一方面作一综述。
Hypoxia-inducible factor (HIF 1) is a nuclear transcription factor that regulates hypoxia-responsive genes and is thought to play an important role in the pathogenesis and progression of tumors, especially hypoxic tumors such as lung cancer. This article intends to make a summary on this aspect.