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目的探讨原发干燥综合征(pSS)和其他结缔组织病(CTD)继发的干燥综合征(CTD/SS)的临床表现、辅助检查及实验室检查特点,进一步提高对SS的认识。方法回顾性对比分析65例SS,其中38例pSS,27例CTD/SS的临床资料。结果 X线双手骨侵蚀、γ-球蛋白阳性率较CTD/SS均明显升高(P<0.05和P<0.01),肾损害以肾间质损害为主,CTD/SS肾损害以肾小球损害为主。结论 pSS和CTD/SS虽然病理诊断一样,但有各自不同的临床表现,在实际工作中需仔细鉴别,避免误诊及漏诊。
Objective To investigate the clinical manifestations, laboratory examinations and auxiliary features of Sjogren’s syndrome (CTD / SS) secondary to primary sjogren’s syndrome (pSS) and other connective tissue diseases (CTDs) and to further improve their understanding of SS. Methods A retrospective analysis of 65 patients with SS, 38 patients with pSS, 27 cases of CTD / SS clinical data. Results X-ray bilateral bone erosion, γ-globulin positive rate than the CTD / SS were significantly increased (P <0.05 and P <0.01), renal damage mainly interstitial damage, CTD / SS renal damage to glomerular Damage-based. Conclusion Although pSS and CTD / SS have the same pathological diagnosis, they have different clinical manifestations. They should be carefully identified in practice to avoid misdiagnosis and missed diagnosis.